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Therapeutic indications
is indicated as an adjunct to general anaesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery.
Dose and method of administration
Like other neuromuscular blocking agents, Vecuronium Bromide should only be administered by, or under supervision of, experienced clinicians who are familiar with the action and use of these agents.
Tracheal intubation
The standard intubating dose during routine anaesthesia is 0.08 to 0.1 mg vecuronium bromide per kg body weight, after which adequate intubation conditions are established within 90 to 120 seconds in nearly all patients.
Dosages of vecuronium bromide for surgical procedures after intubation with suxamethonium Recommended doses:
0.03 to 0.05 mg vecuronium bromide per kg body weight.
If suxamethonium is used for intubation, the administration of Vecuronium Bromide should be delayed until the patient has clinically recovered from the neuromuscular block induced by suxamethonium.
Maintenance dosing:
The recommended maintenance dose is 0.02 to 0.03 mg vecuronium bromide per kg body weight. These maintenance doses should best be given when twitch height has recovered to 25% of control twitch height.
Administration
administered intravenously either as a bolus injection or as a continuous infusion
Reconstitution
Addition of 5 mL water for injection results in an isotonic solution of pH 4 containing 2 mg vecuronium bromide per mL (2 mg/mL).
Audited Supplier
Pharma Sources Insight June 2024: Globalization on the Go
