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Sample Provided: no
Therapeutic indications
Surgery: Atropine may be given as a pre-anaesthetic medication to inhibit excessive salivary and
bronchial secretions and to diminish the risk of vagal inhibition of the heart. The use of atropine as an antisialagogue is rarely necessary since the introduction of halothane and similar anaesthetics in place of ether anaesthesia. Atropine may be administered concurrently with anticholinesterase agents (e.g.neostigmine, physostigmine) to block the adverse muscarinic effects when they are used after surgery to terminate curarisation.
Cardiopulmonary Resuscitation: It may be used in the management of patients with acute myocardial infarction and sinus bradycardia who have associated hypotension and increased ventricular irritability.
Anticholinesterase Poisoning: It is also used concomitantly with a cholinesterase reactivator (e.g.
pralidoxime) to reverse muscarinic effects associated with toxic exposure to anticholinesterase
compounds (e.g. organophosphate pesticides).
Atropine may be used in conjunction with morphine or other agents for the relief of biliary or renal
colic.
Dose and method of administration
Atropine Sulfate Injection may be administered by subcutaneous (SC), intramuscular (IM) or direct
intravenous (IV) injection. Atropine Sulfate Injection contains no antimicrobial agent. It should be used only once and any residue discarded. Atropine Sulfate Injection should not be added to any IV infusion solution.
Surgery
Adults:
300-600 mcg of Atropine Sulfate Injection IM or SC, approximately 1 hour before anaesthesia, usually in conjunction with a narcotic. Alternatively, 300-600 mcg Atropine Sulfate Injection may be given IV immediately prior to induction of anaesthesia. To reverse the effects of non-depolarising muscle relaxants, 600 mcg - 1.2 mg Atropine Sulfate Injection may be given to adults as a slow IV injection in conjunction with the anticholinesterase agent(e.g. neostigmine methylsulphate) of choice.