Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: EU-Poland

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Sample Provided: yes

    Payment Terms: L/C

    Vardenafil hydrochloride

    • Long experience in commercial manufacturing
    • Extensive portfolio of PDE-5 inhibitors (Sildenafil, Tadalafil)
    • Wide regulatory documentation
    Status Commercial
    Therapeutic cat. Erectile
    Polymorphic form Trihydrate form
    CAS No. 330808-88-3
    EU DMF readiness Checkbox
    CEP Checkbox
    CHINESE  DMF Checkbox
    JAPANESE DMF Checkbox
    KOREAN  DMF Checkbox
    CANADIAN  DMF Checkbox
    US DMF readiness Checkbox

    Drug description

    Vardenafil is an oral therapy for erectile dysfunction that selectively inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, which activates guanylate cyclase and increases cGMP synthesis in the smooth muscle cells. PDE5 inhibitors like vardenafil prevent the degradation of cGMP, enhancing blood flow into the penis and resulting in an erection. Vardenafil is more potent than sildenafil and tadalafil in inhibiting PDE5, but it has lower selectivity for other PDE isoforms compared to tadalafil.

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