USP Lopinavir 192725-17-0

Function of Lipinavir

Lipinavir is used in combination with other antiretroviral drugs to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children over 2 years old.

Lopinavir is an HIV protease inhibitor, which can block the division of Gag-Pol polyprotein, resulting in the production of immature, non-infectious virus particles; ritonavir is a kind of HIV-1 and HIV- 2 Peptidomimetic inhibitors of aspartyl protease activity. By inhibiting HIV protease, the enzyme cannot process the precursor of Gag-Pol polyprotein, resulting in the formation of immature HIV particles, which prevents the start of a new infection cycle. Ritonavir can inhibit CYP3A-mediated metabolism of lopinavir, resulting in a higher concentration of lopinavir.

Antiviral activity of Lopinavir: In vitro antiviral drug activity studies in combination with lopinavir have shown that the combination of lopinavir and nelfinavir will increase the antagonistic effect, and it can be compared with amprenavir, atazanavir and indinavir The combined application of Vivi, Saquinavir and Telanavir will increase the synergy. The EC50 value of lopinavir for three different HIV-2 virus strains is between 12~180nM (0.008~113 μg/mL).