Triclabendazole

Information: Triclabendazole is a benzimidazole class anthelminthic agent used for the control of liver fluke infestation in sheep, goats and cattle.
Triclabendazole is a benzimidazole compound used routinely since 1983 in veterinary practice for the treatment of fascioliasis. It was not used in humans until the 1989 epidemic of fascioliasis near the Caspian Sea when Iranian authorities approved the use of the veterinary formulation to treat the infection. {01} {02} (Fascioliasis normally is a disease of domestic herbivorous animals such as sheep, cattle, and goats, which are the normal hosts. Humans are accidental hosts; infection results from eating uncooked, and usually unwashed, aquatic vegetables [e.g., watercress] contaminated with encysted parasitic larvae. Fascioliasis is endemic in 61 countries and has become a foodborne infection of public importance in areas of the world such as the Andean highlands of Bolivia, Ecuador, and Peru, the Nile delta of Egypt, and northern Iran. It is estimated that 2.4 million people are infected worldwide and more than 180 million are at risk of infection.) {01}
Triclabendazole has shown no activity against nematodes. It differs from the other benzimidazole anthelmintics (e.g., albendazole, mebendazole) currently used in humans since these compounds have selective activity against nematodes and have no significant activity against flukes and other trematode helminths. {01} {02}

Molecular Formula: C14H9Cl3N2OS