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Category:Active Pharmaceutical Ingredients
Product Name:Theophylline 58-55-9
CAS No.:58-55-9
Standard:In-house Standards
Price(USD):0.00
Company:Hangzhou Dingyan Chem Co., Ltd
Grade: Pharmaceutical Grade
Factory Location: hangzhou
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
The melting point of 271-273 ° C
The boiling point of 312.97 ° C (rough estimate)
Density 1.3640 (rough estimate)
Index of refraction
Flash point 11 ° C
2-8 ° C storage conditions
The solubility of 0.1 M HCl: soluble
Theophylline causes the smooth muscle tension to drop and the airways to dilate. Can promote the release of endogenous epinephrine, norepinephrine, airway smooth muscle relaxation; Inhibiting the release of calcium ions from the smooth muscle endoplasmic reticulum, reducing the intracellular calcium ion concentration and causing airway dilation. Theophylline relaxes smooth muscle more strongly, but not as much as receptor agonists.
Chemical properties white crystal or crystalline powder, no odor, taste bitter. Mp270-274 ℃. It is soluble in water (1:120), ethanol (1:18), chloroform (1:86), hydroxide lye, ammonia water, dilute hydrochloric acid and dilute nitric acid at room temperature, and slightly soluble in ether. Medium toxicity, LD50(rat, oral)300mg/kg.
Biochemical research, caffeine and other drug synthesis intermediates.
USES: methylpurine drugs. It can strengthen heart, diuresis, dilate coronary artery, relax bronchial smooth muscle and excite central nervous system. Mainly used for the treatment of bronchial asthma, emphysema, bronchitis, cardiac dyspnea.
It is mainly used for the treatment of bronchial and cardiac asthma, and can also be used for cardiac edema
USES phosphodiesterase inhibitors.
USES as pharmaceutical intermediates
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