TAT-cyclo-CLLFVY

Product Name:TAT-cyclo-CLLFVY

Synonyms:CGRKKRRQRRRPPQ;cyclo(CLLFVY) (Disulfide bridge:Cys1-Cys1')

CAS No.:1446322-66-2

Catalog No.:GT-P413

Sequence:H-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH;cyclo(H-Cys-Leu-Leu-Phe-Val-Tyr-OH) (Disulfide bridge:Cys1-Cys1')

Molecular Formula:C41H62N12O11

Molecular Weight:899.02

Key Specification:

Appearance: White powder
Purity(HPLC): ≥98.0%
Single Impurity(HPLC): ≤1.0%
Acetate Content(HPLC): 5.0%～12.0%
Water Content (Karl Fischer): ≤10.0%

Package: 500mg,1g, 5g, 10g, 20g, 50g, 100g, 200g, 500g

Description:

TAT-cyclo-CLLFVY is a dimerization inhibitor peptide with disulfide bond and cyclic structure, with certain selectivity. TAT-cyclo-CLLFVY can block the protein-protein interaction between recombinant HIF-1α and HIF-1β (IC50=1.3μM), but it cannot block the protein-protein interaction between HIF-2α and HIF-1β. TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity and reduces the expression of VEGF and CAIX in osteosarcoma and breast cancer cells. TAT-cyclo-CLLFVY can also reduce the tubulinization of hypoxic HUVECs.

Other services:

Hangzhou Gutuo Biotechnology Co., Ltd. Customized peptide synthesis business:

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Statement:

Sales of the products of the company belongs to the raw materials, only for related qualification enterprise or unit sales, our company provide products only for scientific research, laboratory, not personal selling, more can not be eaten, product efficacy and potential application of agencies involved are from the published literature, not assessed by state food and drug administration, for reference only.No factual evidence.

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