Tadalafil

Name: Tadalafil
Availability: tadalafil-140516.html

Category:Intermediates > Pharmaceutical Intermediates
Product Name:Tadalafil
CAS No.:171596-29-5
Standard:In-house Standards
Price(USD):0.00
Company:Jinan Jianfeng Chemical Co., Ltd.

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: shandong

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: yes

Payment Terms: T/T

Tadalafil Structure

Description

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

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