Spironolactone Tablets

Component:
Spironolactone.

Character:

This product is a film coated tablet, white or white after removing the coating.

Indications:

(1) edematous diseases: combined with other diuretics, it is used to treat edema diseases such as congestive edema, cirrhosis ascites, renal edema, etc. Its purpose is to correct the secondary increase in aldosterone secretion accompanied by the above diseases, and counter the potassium excretion effect of other diuretics. It is also used in the treatment of idiopathic edema.

(2) Hypertension: as an adjunct drug for the treatment of hypertension.

(3) Primary hyperaldosteronism: spironolactone can be used for the diagnosis and treatment of this disease.

(4) Prevention of hypokalemia: combined with thiazide diuretics to enhance diuretic effect and prevent hypokalemia.
 

Usage and dosage:

1. Adults: 

Treatment of edematous diseases: 25 to 125mg daily, divided into 2 to 4 times, for at least 5 consecutive days. Adjust dosage as appropriate later.

Treatment of hypertension: Start with 25 to 100mg daily, taken in batches for at least 2 weeks, adjust the dose as appropriate, and should not be combined with angiotensin-converting enzyme inhibitors to avoid increasing the chance of hyperkalemia.

Treatment of primary hyperaldosteronism: Before surgery, patients should take 100 to 400mg daily, divided into 2 to 4 times. For patients who are not suitable for surgery, a smaller dose is used for maintenance.

Diagnosis of primary hyperaldosteronism: Long-term test, 400mg daily, divided 2 to 4 times for 3 to 4 weeks. Short-term trial, 400mg daily, divided into 2 to 4 times for 4 consecutive days. The elderly are more sensitive to this drug, and the initial dosage should be small.

2. Children: For the treatment of edematous diseases, start taking 1~3mg/kg per day according to body weight or 30~90mg/m2 per body surface area, single or divided into 2~4 times, and adjust the dose as appropriate after 5 consecutive days. The maximum dose is 3 to 9mg/kg or 90 to 270mg/m2 daily.

Matters needing attention:

The blood potassium concentration of the patient should be understood before medication, but in some cases the blood potassium concentration does not represent the total amount of potassium in the body, such as the transfer of potassium from the intracellular to the extracellular and prone to hyperkalemia in acidosis, and the blood potassium can decline after the correction of acidosis.

The action of this drug is slow, and the maintenance time is longer, so the first-day dose can be increased to 2 to 3 times the conventional dose, and the dose can be adjusted later as appropriate. When combined with other diuretics, it can be taken 2 to 3 days before other diuretics. When other diuretic drugs have been applied and this drug is added, the dose of other diuretic drugs can be reduced by 50% in the first 2 to 3 days, and the dose can be adjusted later. When stopping the drug, this drug should be stopped 2-3 days before other diuretic drugs.