Selexipag

Name: Selexipag
Availability: selexipag-269713.html

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:Selexipag
CAS No.:475086-01-2
Standard:ChP, USP, EP, JP
Price(USD):Negotiable
Company:Alicorn Pharmaceutical Co., Ltd

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: Anqing Anhui province

Main Sales Markets: North America,Central/South America,Eastern Europe,Australasia,Middle East,Africa
Monthly Production Capacity: 100kgs per year

Packaging Information: 25kgs per drum
Delivery Lead Time: Deliver in two weeks from PO date

Sample Provided: yes

Payment Terms: T/T

Selexipag (NS-304) is an orally available and long-acting IP receptor agonist prodrug, and its active form, MRE-269, is highly selective for the IP receptor. Selexipag (NS-304) inhibits the binding of [3H]Iloprost to the human and rat IP receptors in a concentration-dependent manner. The Ki is 260 nM for the human IP receptor and 2100 nM for the rat IP receptor. The intracellular cAMP levels in hIP-CHO cells are increased in a concentration-dependent manner by treatment with Selexipag (NS-304) with EC50 of 177nM. Selexipag (NS-304) also inhibits platelet aggregation in humans and monkeys with IC50 values of 5.5 and 3.4 μM, respectively, but it shows no inhibition in dogs

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