Retinaldehyde

Description

Retinal, also known as vitamin A aldehyde,all trans Retinal,retinene, is an oxidized derivative of retinol, which is generated by oxidative cleavage of β-carotene, reduced to retinol, and retinoic acid by oxidation. Retinaldehyde is an intermediate metabolite of natural retinoic acid, has similar biological activity as retinoic acid, and the skin's tolerance to it is significantly better than retinoic acid.

Test Report

Function

Retinaldehyde (RAL) has the characteristics of retinoic acid in the skin, and is better tolerated than retinoic acid. It directly interacts with protein receptors in cells, stimulates skin epidermis to accelerate renewal, increases the thickness of the stratum corneum, and makes the skin It is more compact and orderly; at the same time, it can accelerate the production of collagen in the dermis, prevent the destruction of collagen by UV, inhibit the increase of MMP caused by UV, and make the skin more elastic; the unique aldehyde structure is effective against Propionibacterium acnes, etc. Has a strong inhibitory effect and effectively improves acne-prone skin.

Retinal has many targets on the skin, and when used in skin care products, it can produce multiple effects such as anti-aging, skin rejuvenation, whitening, anti-wrinkle, acne removal, and exfoliation. It is an emerging high-efficiency natural active substance.

Retinal can repair UV-induced loss of elastic fibers and collagen

Can fight skin aging caused by ultrasound and fluid technology

Can effectively improve skin photoaging symptoms

Can effectively inhibit epidermal melanin

Application

Retinal is an anti-wrinkle, anti-aging, and anti-acne skin care active ingredient. Studies have shown that, compared with other commonly used vitamin A derivatives, retinal is less irritating to the skin and more suitable for sensitive skin. In addition, retinoic acid, which is converted into retinoic acid after being metabolized by the human body, also has the effect of curing acne, which can be said to be a multifunctional active additive. Retinal can be used in various anti-wrinkle, anti-aging and anti-acne skin care formulations, and the recommended dosage is about 0.05% to 0.15%.

Ingredient Type: Exfoliating

Efficacy: Promote skin cell renewal, improve skin tone, unclog pores, thicken dermis, slow down the formation of wrinkles

Who should use it: People looking for retinoid anti-aging benefits, can tolerate retinol or retinyl palmitate but have no effect. In this case, retinal can be used, which activates your skin cells more efficiently.

How often you can use it: Allow your skin to get used to the ingredient and eventually use it every day.

DON'T USE: Avoid using any retinoids at the same time as products containing vitamin C, AHA or BHA, this increases the likelihood of sensitivity and irritation, it is recommended to use the former in the morning (under SPF of course) and keep the retinoids For night use.

Delivery real shot

Retinal Chromatogram

Retinal Efficacy Test

Combat skin aging caused by ultrasound and fluid technology

Fig. 1. Mean changes from baseline of epidermal thickness (± SEM) on the forehead and the temple, in the retinaldehyde group and the control group. 

Fig. 2. Mean changes from baseline of dermal thickness (± SEM) on the forehead and the temple, in the retinaldehyde group and the control group. 

Fig. 3.Mean changes from baseline of stiffness (± SEM) on the forehead, in the retinaldehyde group and the control group. 

Fig. 4. Mean changes from baseline of elasticity (± SEM) on the forehead, in the retinaldehyde group and the control group.

Effectively inhibit epidermal melanin

Fig. 1.Changes in objective assessments after 12 weeks of application of RAL 0.05% and RAL 0.1% in patients with photoaged skin.Significant increases in hydration (A), reductions in the TEWL (B), and improvements in the fine wrinkle (C) and skin roughness (F) scores were evident in both groups, but the changes did not differ significantly between the groups. The brightness (L* value) improved to a similar extent in both groups (D). A significant improvement in the melanin index was evident only in the RAL 0.1% group (E) 

Noted: Creams of both 0.1% and 0.05%RAL were well tolerated and improved skin moisture and texture. However, only 0.1 % of RAL cream could improve melanin index.

Effectively improve the symptoms of skin photoaging

Fig. 1. Standardized photographs of the crow’s feet area in subject of the cream , before and at the end of treatment. A, Change in wrinkle depth. B, Change in skin texture