Relugolix

Name: Relugolix
Availability: relugolix-312213.html

Category:Active Pharmaceutical Ingredients
Product Name:Relugolix
CAS No.:737789-87-6
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Company:Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd.

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: Zhongcheng Future Industrial Park, Hangcheng Avenue, Baoan District, Shenzhen

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Asia,Middle East,Africa
Contract Manufacturing: CRO,CMO
Sample Provided: yes

Payment Terms: L/C

Relugolix Biological Activity

Description:Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.target: GnRH [1]IC50: 0.33 nM [1]In vivo: In female knock-in mice, twice-daily oral administration of TAK-385 (100mg/kg) induces constant diestrous phases within the first week, decreases the uterus weight to ovariectomized levels and downregulated GnRH receptor mRNA in the pituitary after 4 weeks.

Molecular Formula:C29H27F2N7O5S

Molecular Weight:623.63

PSA:169.36000

LogP:3.96660

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