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Chiral oxazoborane is a kind of compound of structural unit of phenylethone, which can realize the reduction of high chemical yield and high photochemical yield, and is widely used in the whole synthesis of optically active pharmaceutical intermediates or natural products.It catalyzes the reduction of acetophenone analogues (especially substrates with electron-withdrawing groups on the benzene ring), aromatic ketones, alpha, betaenone, alpha, betaenone, or steric aliphone with BH3, with higher yields and ee values. It can be applied to the following drugs: dinopamine, isopropyladrenalin, salmeterol, formoterol and other beta adrenalin receptor agonists. Catalytic reduction of a variety of substrates, good stereoselectivity, product configuration can be predicted, The product is easy to separate and purify, and the intermediate is easy to recover. The army of chiral drugs says they are widely used in synthesis and industrial production.