Potassium Methoxysalicylate

What Is Potassium Methoxysalicylate?

Potassium methoxysalicylate, whose structure is similar to salicylic acid, is a new type of medicinal whitening ingredient, which is used in cosmetics to play a whitening effect and is a functional ingredient of cosmetics. Potassium 4-methoxysalicylate can coordinate keratin metabolism, correct abnormal epidermal hyperplasia, promote the discharge of melanin, achieve smooth and white skin; it can also block the source of melanin melanin production, and has the ability to improve self-healing , it can be used in conjunction with various types of whitening products to improve the whitening effect and has a good development prospect.

Test Report

What Are The Benefits? 

1. The effect of inhibiting melanin production

After the mouse melanoma cells (B16) were cultured for three days with and without 4-methoxypotassium salicylate, the number of cells and the amount of melanin under a certain number of cells were detected. quantity. The effect of 4-methoxypotassium salicylate on melanin production was analyzed by obtaining the ratio of the number of cells and the amount of melanin when 4-methoxypotassium salicylate was added compared to when no 4-methoxypotassium salicylate was added. effect.

2. Inhibition of tyrosinase activity

For the evaluation of tyrosinase activity in cell-free system, L-DOPA was used as the matrix, and the amount of dopachrome produced by its metabolism was detected by the method of absorbance at 475mn. The inhibitory rate of tyrosinase activity is obtained by adding 4-methoxysalicylate potassium solution and solvent to the above reaction system, and reacting the mixture at room temperature for 90 seconds. Compared with the solvent group, the addition 4-Methoxysalicylate Potassium Solution Ratio of Test Values.

3. It has an inhibitory effect on the differentiation of keratinocytes caused by ultraviolet rays

After irradiating the three-dimensional skin model with ultraviolet rays, immediately add 4-methoxy potassium salicylate solution on the surface of the skin model, cultivate for 30 minutes, remove the 4-methoxy potassium salicylate and continue to culture for 1 day. Controlled with vehicle instead of potassium 4-methoxysalicylate solution. For the skin model sampled after culture, the immunohistochemical study was carried out by anti-loricrin antibody staining and the quantification of loricrin mRNA expression was carried out by real-time R-TPcR (reverse transcription polymerase chain reaction).

4. Anti-pigmentation effect on human body

In 4 abdomens of 12 healthy adult male volunteers, each tester was irradiated once a day with ultraviolet light of UV gas and UVB wavelengths, equivalent to IMED, for 3 consecutive days. Four kinds of creams mixed with 1%, 3%, 5% 4-methoxysalicylate potassium cream and base cream were used as test samples, and were applied continuously 3 times a day from the beginning of ultraviolet irradiation. Apply for 7 days. When evaluating the degree of pigmentation, use a color tester to measure the skin color (L* value) before and after applying the sample three times, obtain the average value, and obtain the change (△L*) before and after irradiation. Potassium 4-methoxysalicylate cream application site and base cream application site.

Application Direction

The main function of 4MSK is to let the ultraviolet radiation cause the disorder and overlapping of the stratum corneum, resulting in dark spots and freckles caused by chronic abnormal keratosis. The source is indeed blocked, which can inhibit the production of melanin and prevent the occurrence of dark spots and freckles. Therefore, it is widely used in the field of cosmetics

Company Introduction And Certificates Obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.