Basic Info
  • Grade: Food Grade

    Factory Location: Shaanxi

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Sample Provided: yes

    Payment Terms: T/T

    What is phloretin?

     

    Phloretin powder is a new type of natural skin whitening agent developed by new research, mainly derived from the peel and root bark of apples. As a functional cosmetic raw material, it has attracted extensive attention from researchers in the beauty industry. It is also a flavonoid compound with dihydrochalcone structure, which has antioxidant, anti-inflammatory, whitening, sunscreen, antibacterial, moisturizing and other functions, and has been used in cosmetics.

    Product Details Form

    CAS 60-82-2
    MF C15H14O5
    MW 274.27
    EINECS 200-488-7
    Melting point ~260°C
    Boiling point 337.26°C (roughestimate)
    Density 1.1827 (roughestimate)
    FEMA 4390
    Refractive index 1.573-1.575
    Acidity coefficient (pKa) 7.16±0.40 (Predicted)
    Solubility Soluble in methanol, ethanol and acetone
    MDL number MFCD00002288
    PubChem number 24278652
    BRN number 1887240

    What are the benefits for the skin?

     

    1. Antioxidant, Anti Free Radical

    Phloretin powder has strong antioxidant properties, has an antioxidant effect on oils, and can scavenge free radicals in the skin.

     

    2. Whitening Spots

    Its whitening mechanism is mainly to inhibit the activity of tyrosinase in the body, thereby reducing the production of melanin in the body.

     

    3. Promote Transdermal Absorption

    is a lipophilic compound that penetrates into the skin via intercellular lipids

     

    4. Anti-Inflammatory Activity

    Regarding anti-inflammatory experiments, in vitro studies have shown that it can inhibit the production of inflammatory factors, chemokines and differentiation factors

     

    5. Sunscreen

    It has a certain UV absorption capacity, and it can be added to the basic formula of cosmetics to improve the SPF and SPA value of cosmetics.

     

    6. Antibacterial Activity

    is a flavonoid compound with antibacterial activity

     

    7. Moisturizing Effect

    The 4 hydroxyl groups contained in the molecule can form hydrogen bonds with water molecules, absorb water, and have potential moisturizing effects. Therefore, it can also be used as a natural moisturizing agent in moisturizing cosmetics.

     

    8. Anti-Hair Loss Effect

    Studies have shown that it can inhibit the activity of soybean lipoxygenase, thereby reducing the loss of hair due to premature aging.

    Product Usage & Recommended Dosage

     

    Specification

    Recommended dose

    Phloretin 98%

    0.3%-2.0%

    Phloretin powder is widely used in masks, lotions, essences, creams, sunscreens, shampoos, conditioners and other types of cosmetics and care products.

    Phloretin

    Cosmetic

    It is widely used in the field of cosmetics for its whitening, moisturizing and other effects

     

    Health products

    Antioxidant, free radical scavenging, anti-inflammatory and immunosuppressive effects

     

    Flavor, spice

    1. Inhibit bitterness and other unpleasant tastes in food and improve taste

    2. Reduce the odor of high-intensity sweeteners and mask undesired flavors

    3. Use with stevia as a taste modifier

    Process flow

     

    Phloretin process

    Studies on Phloretin and Cosmetics:

     

    Pilot projects

    Concentration

    Effect description

    Elimination of free radical DPPH

    32umol/L

    Elimination rate: 74.6%

    Inhibition of lipid peroxidation

    13umol/L

    Inhibition rate: 53%

    Promotion of type 4 collagen production by phloretin in cell culture

    25ug/mL

    Promotion rate: 201.6±20.6 (blank 100)

    The protection of phloretin on apoptosis of stratum corneum cells under 1.0J/cm2 UVB irradiation

    400ug/mL

    Protection rate: 51.3%v9.6%

    The promotion of brain amide production by phloretin in cell culture

    2umol/L

    Promotion rate: 164 (blank 100)

    Inhibition of tyrosinase activity

    0.05%

    Inhibition rate: 82.2%

    Inhibition of hyaluronidase activity

    100ug/mL

    Inhibition rate: 93.5%

    Inhibition of 5α-reductase activity

     

    Half inhibitory dose IC50: 84.3ug/mL

    Inhibition of metalloprotease MMP-1 activity

    5umol/L

    Inhibition rate: 78%

    Inhibition of interleukin IL-4 production

     

    Half inhibitory dose IC50: >30umol/L

    Inhibition of β-hexosaminidase activity

    100ug/mL

    Inhibition rate: 93.5%

    Inhibition of transepidermal water evaporation by coating phloretin

    50umol/L

    Inhibition rate: 25% (compared with blank)

    Company introduction and certificates obtained

    YTBIO mainly supplies Phloretin powder and other products. The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA etc. We always maintain the highest demands on product quality.

    Certificate

    Our packaging

    Our packing method is 1KG/Aluminium bags, 25kg/drum

    For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

    Package3

    Our team

    Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.

    team3

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