Pharmaceutical Grade Finerenone API

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:Pharmaceutical Grade Finerenone API
CAS No.:1050477-31-0
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Price(USD):$2000/kg-$3000/kg
Company:Shandong Loncom Pharmaceutical Co.,Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Shandong

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Monthly Production Capacity: 100kg

    Contract Manufacturing: CRO,CMO

    Packaging Information: 5kg/drum

  • Delivery Lead Time: 15days

    Sample Provided: yes

    Payment Terms: L/C

     

    Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with type II diabetes mellitus. Patients with kidney disease, would originally be given [spironolactone] or [eplerenone] to antagonize the mineraclocorticoid receptor. Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and can also have effects at the androgen, progesterone, and glucocorticoid receptors. Eplerenone is more selective and has longer lasting effects. More selective nonsteroidal mineralocorticoid antagonists such as [apararenone], [esaxerenone], and finerenone were later developed. So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved. Finerenone was granted FDA approval on 9 July 2021, followed by the EMA approval on 11 March 2022.

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