Pharmaceutical Grade API Lacosamide CAS 175481-36-4

Product Description

Product name Lacosamide

Synonyms (R)-2-Acetamido-N-benzyl-3-methoxypropanamide

CAS 175481-36-4

Molecular Formula C13H18N2O3

Molecular Weight 250.29

Product Feature

Apperance White or off white crystalline powder

Identification IR; HPLC

Melting point 140－145℃

Specific rotation +14º－+17º

Water (KF) NMT 0.5%

Residue on ignition NMT 0.3%

Heavy metals NMT 30PPM

Max single impurity: NMT 0.5%

Total impurity: NMT 1.0%

S -isomer NMT 1.0%

Assay (HPLC ) 98.0－102.0%

Lacosamide is a functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.