Pharmaceutical Grade API Daprodustat CAS 960539-70-2

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:Pharmaceutical Grade API Daprodustat CAS 960539-70-2
CAS No.:960539-70-2
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Price(USD):$1000/kg-$2000/kg
Company:Shandong Loncom Pharmaceutical Co.,Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Shandong

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Monthly Production Capacity: 100kg

    Contract Manufacturing: CRO,CMO

    Packaging Information: 5kg/drum

  • Delivery Lead Time: 15days

    Sample Provided: yes

    Payment Terms: T/T

    Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK. Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces erythropoiesis. A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, daprodustat was non-inferior to erythropoiesis-stimulating agents regarding the change in the hemoglobin level from baseline and cardiovascular outcomes.

    In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia.On October 2022, the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported that the benefit of treatment with daprodustat outweighs the risks for adult dialysis patients with anemia of CKD but not for non-dialysis patients with anemia of CKD.7 On February 1, 2023, daprodustat was fully approved by the FDA as the first oral treatment for anemia caused by chronic kidney disease in patients on dialysis.9 The drug is currently under EMA review.

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