Natural Paclitaxel

Paclitaxel is a complex secondary metabolite extracted from the bark of Taxus taxus. It is also the only drug known to promote microtubule polymerization and stabilize polymerized microtubules. The isotope tracer showed that paclitaxel was only bound to the polymerized microtubules and did not react with the unpolymerized tubulin dimer. After contact with paclitaxel, cells will accumulate a large number of microtubules in the cell, and the accumulation of these microtubules interferes with various functions of the cell, especially the cell division stops in the mitosis period and blocks the normal division of the cell. Through Ⅱ-Ⅲ clinical studies, paclitaxel is mainly suitable for ovarian cancer and breast cancer, lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, brain tumor also have a certain effect.