Microfluidic ‒ Nano Medicine Preparation System

Microfluidic is a technology capable of controlling and manipulating liquid flow in micron-scale dimensions. Based on the theory of microfluidics, it combines process control technology with process analysis technology to achieve good on-line sample preparation. The parameters in the process are completely controllable and have good reproducibility, so it is more scalable than the traditional method of step-by-step preparation and batch production. It can realize the functions of primary emulsification, double emulsification, and particle size control of samples. The microfluidic preparation system is connected to the microfluidic chip through the preparation pump and the high-pressure delivery pump, and phase A and phase B can be transported to the chip at a constant speed accord ing to a certain ratio for mixing and emulsification. In the microfluidic chip, by designing different flow channel structures and controlling different speeds, the sample can reach turbulent flow, laminar flow or atomization state, so that it can reach the required range of small particle size below 100 nm and PDI below 0.1. Based on microfluidic technology, the synthesis process can be precisely controlled, and prepare nanocarriers with narrower particle size distribution, higher drug loading and better stability, and the technology is highly repeatable. Therefore, microfluid ic technology has great application prospects in the production of nano medicines. Duoning provides microfluidic systems of different specifications from laboratory to production.