miconazole nitrate 22832-87-7 (75319-48-1)

Miconazole nitrate is an antifungal drug. This product can inhibit the growth of most fungi at the concentration of 4mg/L, and the genera of bacillus and histoplasma are highly sensitive to it. Cryptococcus, candida and coccidioides are also sensitive to this product. By interfering with the activity of cytochrome p-450, the biosynthesis of ergosterol, the main sterol in the fungal cell membrane, can be inhibited, and the fungal cell membrane can be damaged and its permeability can be changed, so that important intracellular substances leak out. It can also inhibit the biosynthesis of triacylglycerol and phospholipid of fungi, inhibit the activity of oxidase and peroxidase, and cause the accumulation of hydrogen peroxide in cells, leading to the degeneration of cell submicrostructure and cell necrosis. Candida albicans inhibited the transformation from spores to invasive hyphae.

The product is white or white crystal or crystalline powder; Odorless or almost odorless. The product is slightly soluble in methanol, slightly soluble in chloroform or ethanol, and insoluble in water or ether. The melting point of the goods (appendix Ⅵ C) should be 178 ~ 184 ℃, melting and decomposition.