Magnolia officinalis P.E.

Product information

[Description]

Magnolia is used as a general anti-stress and anti-anxiety agent - so its claims typically center on general benefits in controlling stress and anxiety.Newer claims are emerging, however, to link magnolia's anti-stress benefits with control of the body's primary stress hormone, cortisol, and the myriad health benefits associated with normal cortisol levels (versus elevated cortisol, which has been associated with obesity, diabetes, osteoporosis, memory problems and suppressed immune function).
Magnolia is rich in two biphenol compounds, (magnolol and honokiol), which are thought to contribute to the primary anti-stress and cortisol -lowering effects of the plant. The magnolol content of magnolia bark is generally in the range of 2-10 percent, while honokiol tends to occur naturally at 1-5 percent in dried magnolia bark. Magnolia bark also contains a bit less than 1 percent of an essential oil known as eudesmol, which is classified as a triterpene compound, and may provide some additional benefits as an antioxidant.

[Function]

1. Honokiol has been used in the traditional Japanese medicine as an anxiolytic, anti-thrombotic, anti-depressant, anti-emetic, and anti-bacterial.

2. Anti-tumorigenic activities
Honokiol has shown pro-apoptotic effects in melanoma,sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.

3. Anti-thrombolytic
Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density liproptein injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1 alpha, potentially the key factor in honokiols anti-thrombotic activity.

4. Neurotrophic Activity
Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons

[Applications]

1· Applied in pharmaceutical field, it is mainly used as pharmaceutical materail to treat asthenia
of kidney, impotence, spermatorrhea, prospermia, cold extremities, acroanesthesia or convulsion, etc.
2· Applied in the field of health care products, it was used in capsules, health food, oral liquid, health
care wine and other alcoholic beverages,
which has good health-care effect on human cardiovascular and endocrine system, delaying aging.

[Storage] Store in cool & dry place, Keep away from strong light and heat.

[Shelf Life] 2 years if sealed and store away from direct sun light.