Loputinib

Name: Loputinib
Availability: loputinib-343799.html

Category:Active Pharmaceutical Ingredients
Product Name:Loputinib
CAS No.:1802220-02-5
Standard:In-house Standards
Price(USD):Negotiable
Company:Shanghai Hope-chem Co.,Ltd.

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Basic Info

Grade: pharmaceutical grade

Factory Location: Shanghai

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no

Lofitinib is an oral inhibitor of various kinases, including receptor tyrosine kinase asexual lymphoma kinase (ALK), c-ros tumor gene 1 (ROS1), neurotrophic tyrosine receptor kinase (NTRK) types 1, 2, and 3, oncogene SRC, and focal adhesion kinase (FAK), with potential anti-tumor activity. After oral administration, rapatinib binds to wild-type, point mutants, and fusion proteins of ALK, ROS1, NTRK1-3, SRC, and FAK and inhibits them to a lesser extent, while inhibiting other kinases. Inhibiting these kinases can lead to the disruption of downstream signaling pathways and inhibit the cell growth of tumors with overexpression, rearrangement, or mutation of these kinases.

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