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Category:Natural Extracts > Plant Extracts
Product Name:Leech Extract powder -Hirudin 98%
CAS No.:113274-56-9
Standard:ChP
Price(USD):50.00
Company:Xi`an Changyue Biological Technology Co., Ltd,
Grade: Pharmaceutical Grade
Factory Location: Xi'an Shaanxi China
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Monthly Production Capacity: 4000kg
Packaging Information: 25kg/drum
Delivery Lead Time: within 7 days
Sample Provided: yes
Payment Terms: T/T
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2.ISO,GMP,KOSHER, HALAL,FDA
3.Excellent quality, competitive price
4.Free sample
leech extract powder Hirudin
CAS: 113274-56-9
Molecular formula: C66H93N13O25
Formulation: white fine powder
Purity: 98
leech extract powder Hirudin
Product description
Product: Hirudin
CAS: 113274-56-9
Molecular formula: C66H93N13O25
Formulation: white fine powder
Purity: 98%
Function
A,Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches’ alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin
B,Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III.
C,Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.
D,Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.
Package&Storage
Package: 1kg/one plastic bag and aluminium foil bag outside,
25kg/Fiber Drums with double plastic bags inside.Storage: 2 years properly stored.
Pharmacology
Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches’ alimentary habit of hematophagy, since it
keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin.A key event in the final stages of blood coagulation is the convertion of fibrinogen into fibrin by the serine protease enzyme
thrombin.
Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in
normal blood circulation is antithrombin III.
Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the procoagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin
binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.
Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial
varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the
biological activity of other serum proteins and can also act on complexed thrombin
Product description: Hirudin is the most significant active constituents, is extracted from leech and its salivary glands, and is a kind of small molecule protein (polypeptide) which comprised of 65-66 amino acid.
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