L-Arabinose

L-Arabinose is a naturally occurring pentose with  a sweet taste and is widely distributed as a component of complex non-starch polysaccharides in plant cell walls  and plant  gums. 

As a low-calorie sugar-substituting sweetener, the relative sweetness of L-Arabinose equals to half of the Sucrose’s.  Some research suggested that L-Arabinose selectively inhibit sucrose absorption and then inhibit the increase of blood sugar.

Furthermore, L-Arabinose is an intermediate in flavor industry for producing flavors, the derivates of L-Arabinose can be used in the development of antiviral agents such as nucleoside.

Properties

CAS No:	5328-37-0
EINECS:	226-214-6
Alias Name:	L-(+)-Arabinose; L-Arabinopyranose
Chemical Structure:
Molecular Formula:	C5H10O5
Molecular Weight:	150.13
Assay:	NLT 99.0%
Solubility:	Easily soluble in water, slight soluble in alcohol
Specific Rotation:	+101º to +105º
Application:	Intermediate for nucleoside derivates synthesis Intermediate for flavors synthesis Ingredient in function food Food additive in foods, drinks

History

-1970's,   L-Arabinose has been listed as GRAS flavor ingredient (No.3255) by The Flavor and Extract Manufacturers Association of the United States

-2003 or before,  L-Arabinose was approved as ingredient relative to blood sugar level for "Food with health claims (permit required for each item)" by Ministry of Health, Labour and Welfare of Japan. 

-2007, L-Arabinose was listed as food additive in Japan's Specifications and Standards for Food Additives (8th Edition)

-2008, L-Arabinose  was approved as new resource food which can be used as ingredient in general food by Ministry of Health of China  (Announcement No. 12 on 2008).

-2013 or before,  L-Arabinose was listed in  EAFUS (Everything Added to Food in the United States)  by USFDA.   (Doc no. 0088,  Doc type ASP)

- 2018, L-Arabinose is listed as food additive in Japan's Specifications and Standards for Food Additives (9th Edition)

Benefits

Sugar-substituting sweetener

L-Arabinose has a nice, sweet taste that does not linger in the mouth and has no aftertaste. No-calorie sweeter, it's not metabolized in humans. No side-effects were reported

Inhibiting sucrose absorption

The sucrase enzyme normally splits the sucrose molecule into one D-glucose and one D-fructose molecule. During the period that the sucrase enzyme is inhibited by L-Arabinose, the splitting of sucrose is delayed or even prevented, and the release of D-glucose and D-fructose to the blood is delayed.

Therefore L-Arabinose selectively inhibits the sucrase enzyme in the small-intestine in an uncompetitive manner.

Dosage: add 3% -5% L-Arabinose in Sucrose.

Raw material for Drug Synthesis

L-Nucleosides and their analogues have become useful agents for the treatment of viral diseases due in part to their good antiviral activity and generally low toxicity.

Yixin’s advantages

Plant-derived,  100% Non-GMO Source

Yixin’s plant derived L-Arabinose is completely from nature tree, non GMO source. It does NOT have any GMO risk, neither Yixin nor any of Yixin suppliers of raw materials has used Genetically Modified Organisms in this product. 

GMO High Risk Crops & Inputs -Crops Alfalfa, Canola, Corn (except popcorn), Cotton, Papaya, Soy, Sugar beet, Zucchini/Yellow summer squash, Canola -Animal Derivatives Meat, Eggs, Milk, Products of Apiculture (e.g., Honey), Products of Aquaculture (e.g., Fish), Gelatin, Hides and Skin -Microbes and Microbial Products Enzymes (e.g., chymosin), Cultures and starters including yeast, Algae from aquaculture   Refer to https://www.nongmoproject.org/gmo-facts/high-risk/

Clean Technology

Yixin plant derived L-arabinose is produced by clean technology, during the whole production process, only water is used as extraction solvent to ensure the environmental sustainability and the process safety.

Low Impurity Profile 

Yixin plant derived L-arabinose is produced under GMP system, every batch is tested for its chemical impurities and chiral impurity to meet the quality requirements both in pharmaceutical and food industry.

Allergen Free

Food allergies occur when the body's immune system reacts to a foreign substance. Food allergic reactions vary in severity from mild symptoms involving hives and lip swelling to severe, life-threatening symptoms, often called anaphylaxis, that may involve fatal respiratory problems and shock.

Our plant derived L-arabinose is produced by extraction of raw material of vegetable origin. It does NOT contain any of the allergens in below list.

• milk and products thereof (including lactose)
• fish and products thereof including roe, molluscs and products thereof, crustaceans and products thereof,
• eggs and products thereof
• cereals containing gluten; namely:
  wheat, rye, barley, oats, spelt, kamut or their hybridised strains and products thereof
• buckwheat
• soybeans and products thereof
• nuts; namely:
  almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts,
  macadamia or Queensland nuts, pine nuts, chest nuts and products thereof
  other tree nuts including coconut
• peanuts and products thereof
• sesame seeds and products thereof
• celery and products thereof
• mustard and products thereof
• sulfur dioxide, sulphites, at concentrations of more than 10 mg/kg or 10 mg/litre
• coriander
• cocoa
• maize
• glutamate
• natural rubber latex
• chicken, beef, pork,
• legumes/pulses,lupines and products thereof, carrot

GMP  system

Yixin plant derived L-arabinose is produced under GMP system to ensure the traceability and consistent supply. Yixin GMP system was  established and improved over  20 years,  for carbohydrates facility,  NSF GMP certificate has been obtained since 2015, In 2015 Yixin carbohydrate facility was inspected  and concluded by US FDA to meet the related requirements.

-In 2015-2018 Yixin Carbohydrates facility was assessed by NSF international and found to be in compliance with GMP Requirements in NSF/ANSI Standard173,Section B Dietary Supplements.

-Yixin Carbohydrates Facility was inspected in 2015 by US.FDA, it’s concluded to meet the related requirement of Dietary Supplement Ingredient.

-In 2015-2018 Yixin Carbohydrates facility were certificated by 3rd Kosher certification organization.

-Since 2002, Yixin has obtained the Certificates of GMP from CFDA for 9 dosage forms successively including capsules, tablets, syrup, preparation for external use and  etc. In 2006 and 2011 Yixin facility of API was inspected and classified as acceptable by US FDA.