Indole-3-Carbinol

Products Description:

Indole-3-Carbinol is a type of Indole. Chemically, it is a metabolite of Glucobrassicin, which in turn is a hydrolytic product of Glucosinolates.
 
Health Benefits of Indole-3-Carbinol
Immune System 
Indole-3-Carbinol may prevent and suppress the progression of some forms of Cancer:

Indole-3-Carbinol may suppress those forms of Cancer that are initiated by Papilloma Viruses (by modulating Estrogen metabolism).
Indole-3-Carbinol may help to prevent some forms of Cancer by facilitating the binding of various carcinogens to Glucuronic Acid to form Glucuronides.
Indole-3-Carbinol may reduce the ability of Heterocyclic Aromatic Amines (HAAs) (e.g. PhlP) to initiate Cancer and may reduce the ability of HAAs to damage the body’s endogenous Deoxyribonucleic Acid (DNA). 
Indole-3-Carbinol may maintain the integrity of the p53 Tumor Suppressor Gene (a Gene that helps to prevent Cancer).

Indole-3-Carbinol may help to prevent Breast Cancer by stimulating the conversion of Estrone (the Estrogen which is known to cause Breast Cancer in excess) to its metabolite 2-Hydroxyestrone (an inactive metabolite). 
Indole-3-Carbinol may help to prevent Cervical Cancer (especially Papilloma Virus (HPV-16)-initiated Cervical Cancer):

The principal underlying mechanism for the ability of Indole-3-Carbinol to prevent Cervical Cancer involves the ability of Indole-3-Carbinol to inhibit the ability of Papilloma Virus 16 to stimulate the conversion of Estrone to 16-Hydroxyestrone (a byproduct of Estrone that is a known initiator of Cervical Cancer).

Indole-3-Carbinol may counteract the ability of many dietary carcinogens to initiate Colon Cancer. 
Indole-3-Carbinol may inhbit the development of Endometrial Cancer. 
Indole-3-Carbinol may help to prevent Leukemia. 
Indole-3-Carbinol may help to prevent Liver Cancer:

Indole-3-Carbinol may inhibit the ability of Aflatoxin to cause Liver Cancer.

Indole-3-Carbinol may help to prevent Ovarian Cancer. 
Indole-3-Carbinol may help to prevent Prostate Cancer (by modulating the effects of Estrogens in Aryl Hydrocarbon Receptors in Prostate cells). 
Indole-3-Carbinol may help to prevent Skin Cancer (especially Papilloma Virus-induced Skin Cancer):

Indole-3-Carbinol may help to prevent Squamous Cell Carcinoma (especially Papilloma Virus-induced Squamous Cell Carcinoma).

Indole-3-Carbinol may prolong lifespan in Systemic Lupus Erythematosus (SLE) patients.

Metabolism

Preliminary reports indicate that Indole-3-Carbinol may alleviate some of the symptoms of Chronic Fatigue Syndrome (CFS). [more info]
Indole-3-Carbinol may stimulate the endogenous production of Glutathione by Liver Cells (hepatocytes).

Musculoskeletal System

Preliminary reports indicate that Indole-3-Carbinol may alleviate some of the symptoms of Fibromyalgia. [more info]

Indole-3-Carbinol may Enhance the Production/Function of these Substances

Carbohydrates

Indole-3-Carbinol may facilitate the binding of various substances (including carcinogens) to Glucuronic Acid to form Glucuronides (for excretion). [more info]

Hormones

Indole-3-Carbinol may inhibit the conversion of Estrone to 16-Hydroxyestrone (a carcinogenic metabolite of Estrone) and may redirect Estrone to be converted to 2-Hydroxyestrone (a safe metabolite of Estrone).

Indoles

Indole-3-Carbinol is a constituent of Ascorbigen. 
Indole-3-Carbinol is metabolized to Diindolylmethane (recent research indicates that Diindolylmethane is the compound that is actually responsible for the health benefits formerly attributed to Indole-3-Carbinol). Chemically, Diindolylmethane consists of two molecules of Indole-3-Carbinol bound together.

Nucleic Acids

Indole-3-Carbinol may reduce the ability of Heterocyclic Aromatic Amines (HAAs) (e.g. PhlP) to damage the body’s endogenous Deoxyribonucleic Acid (DNA).

Peptides

Indole-3-Carbinol may stimulate the endogenous production of Glutathione by Liver Cells (hepatocytes). [more info]

Indole-3-Carbinol may Counteract these Potentially Toxic Substances

Amines

Indole-3-Carbinol may reduce the ability of some types of Heterocyclic Aromatic Amines (HAAs) (e.g. PhlP) to initiate Cancer and may reduce the ability of HAAs to damage the body’s endogenous Deoxyribonucleic Acid (DNA).

Environmental Toxins

Indole-3-Carbinol may counteract the toxic effects of Dioxin.

Hormones

Indole-3-Carbinol may stimulate the conversion of Estrone to its inactive (safe) metabolite, 2-Hydroxyestrone, and inhibits the conversion of Estrone to its carcinogenic metabolite, 16-Hydroxyestrone.