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Therapeutic indications
Doxycycline is indicated in the treatment of uncomplicated chest, urethral, endocervical or rectal
infections in adults caused by susceptible organisms as shown by culture and sensitivity testing. It may also be a useful adjunct to amoebicides in acute intestinal amoebiasis and has a place as adjunctive therapy in severe acne.
Dose and method of administration
The usual dose in adults is 200 mg on the first day of treatment followed by a maintenance dose of 100 mg/day. This may be given as either a single dose or divided doses administered every 12hours.
In the management of more severe infections, 200 mg daily should be given throughout the treatment period. Therapy should be continued at least 24 - 48 hours after symptoms and fever has subsided. If used in streptococcal infections, therapy should be continued for 10 days to prevent the development of rheumatic fever or glomerulonephritis.
For children over 12 years of age, the recommended dosage schedule for those under 50 kg is 4 mg/kg on the first day and 2 mg/kg daily subsequently. For children over 50 kg the usual adult dose is used. In the treatment of acute gonococcal anterior urethreitus in males, administer either: 200 mg statand 100 mg at bedtime on the first day followed by 100 mg twice daily for 3-7 days, or 300 mg stat followed by 300 mg one hour later. For acute gonococcal infections in females use 200 mg twicedaily until cure is effected. When treating uncomplicated urethral, endocervical or rectal infection in adults caused by chlamydia trachomatis, give 100 mg twice daily for at least 7 days. The treatment of primary or secondary syphilis requires 300 mg daily in divided doses for at least 10 days.
Follow all directions given to you by your doctor and pharmacist carefully
Audited Supplier
Pharma Sources Insight June 2024: Globalization on the Go
