FiltraLinX® Depth Filter Holder (Type P3C)

The depth filtration system is designed to remove large cell particles in the preparation of biological products, such as cell clar- ification (in bioreactor rooms) or intermediate product filtration (in purification rooms). The system consists of a power unit, a cassette holder, a detection unit, and an automatic control unit. In this document, we will focus on the cassette holder.

The depth filter holder is used to hold deep filtration cassettes of a given area. Under the action of a power pump, the feed liq- uid passes through the cassettes, which intercepts the solid particles in the liquid for clarification. The product is designed to meet the needs for laboratory research and development, pilot-scale production, and large-scale production. It is suitable for a variety of primary and secondary clarification and filtration applications, including mammalian cell culture media, yeast cul- ture media, E. coli lysate, E. coli renaturation buffer, pharmaceutical intermediates, culture media, plasma proteins, and serum.

The vertical P3C series fixture design is particularly suitable for biopharmaceutical process. It is very simple, safe, and intuitive to use, occupying little space.

• Compatible with prevalent round deep filtration cassettes on the market;
• The position of the top turnplate and the distance of the guide rod can be adjusted according to the number of cassettes, so as to properly hold different numbers of cassettes;
• The ergonomic design allows for loading, filtering and disassembling in the vertical direction;
• Resistant to the disinfection by acid, alkali, organic solvents, and other disinfectants, meeting the requirements for CIP and cleaning validation;
• Easy to install and use and ready for production, allowing assembly, operation and disassembly steps to be performed in- dependently by the user;
• Carefully designed, highly performing, technically innovative, energy efficient, safe and reliable, and easy to maintain;
• Made of SS 316L stainless steel, without compromising the cleanliness of the pharmaceutical production environment;
• Smooth surface for easy cleaning;
• Surface polished Ra < 1.2 μm, polished part in contact with the product Ra < 0.5 μm;
• Material certificates are available;
• Adopts cGMP, EU GMP and FDA certified food grade lubricants;
• Complete set of accessories;
• Equipped with 4 lockable wheels;
• It works with a deflector to offer a variety of working modes, such as down-in & up-out, up-in & down-out, down-in & down- out, series filtration and parallel filtration, for enhanced flexibility in different processing applications;
• Smaller residual volume for higher recovery rates.

For more information, please visit Bio-Link website.