ENRAMYCIN

□ Chemical abstract service (CAS) registry number: 11115-82-5

□ Molecular formula:

   Enramycin A (C₁₀₇H₁₃₈Cl₂N₂₆O₃₁)

   Enramycin B (C₁₀₈H₁₄₀Cl₂N₂₆O₃₁)

□ The relative molecular weight:

   Enramycin A: 2352.9398

   Enramycin B:2366.9555

□ Characterization: Grey or beige powder, with special odor.

□ Loss on drying: Not more than 8.0%.

□ Particle size: 100% passes the 24 mesh sieve.

□ Heavy metals: Not more than 0.002%.

□ Arsenic: Not more than 0.0004%.

□ Assay: Should be 90.0%~110.0% of the labeled amount.

□ Efficacy

    Enramycin has a strong antibacterial effect on Clostridium, streptococcus, Staphylococcus and Diplococcus pneumonia etc. under both aerobic and anaerobic conditions. The main mechanism is restrain the formation of cell wall of bacteria. It acts at the stage of schizogenesis, has effects of disinfection and lysis. Minimum inhibitory concentration(MIC) is lower than 0.39～3.12ug/ml. Thereinto, the MIC on Staphylococcus aureus is between 0.78～ 1.56 ug/ml, the MIC on Streptococcus hemolyticus  and Streptococcus faecium are 0.045 ug/ml and 3.12 ug/ml, the MIC on Clostridium perfringens such as Bacillus tetani, Botox, Clostridium welchii etc. is lower than 0.78 ug/ml. Enramycin hardly has antibacterial effect on Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa,Salmonella,  Shigella etc. and the MIC on them is more than 100 ug/ml.

    Enramycin is an excellent growth-promoter and improves feed efficiency at very low inclusion levels in feed. Growth promotion and improved feed efficiency were observed in both broilers and pigs when Enramycin was incorporated in feed.

□ Indications: Antibiotics for Gram-positive bacteria, growth-promoter for poultry and pig.

□ Usage and dosage

* For Broiler:

For necrotic enteritis: 8g to 12g (Calculate as active ingredient) per 1000kgs feed, for about 20 days.

As growth promoter: whole stages

- Starter and pre-starter feed: 5g to 10g (Calculate as active ingredient) per 1000kgs feed

- Finisher and withdrawal feed: 3g to 10g (Calculate as active ingredient) per 1000kgs feed

- Layers and breeders: 5g to 10g (Calculate as active ingredient) per 1000kgs feed

* For Pig:

As antibiotics: 12g to 20g (Calculate as active ingredient) per 1000kgs feed

As growth promoter:

- Piglet feed: 8g to 10g (Calculate as active ingredient) per 1000kgs feed

- Finisher and withdrawal feed: 5g (Calculate as active ingredient) per 1000kgs feed

- Breeders: 15g to 20g (Calculate as active ingredient) per 1000kgs feed

□ Withdrawal period: 7 days.

□ Storage: Tightly sealed, store in a dry and dark place.

□ Shelf life: 2 years.

□ Content: 4%, 8%, 10%, 12%