Emedastine difumarate

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:Emedastine difumarate
CAS No.:87233-62-3
Standard:ChP, USP, BP, EP, JP
Price(USD):0.00
International Approvals/Standards:ISO9001:2000
Company:Zhongbao Chemicals Co., Limited.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Hangzhou Zhejiang China

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Sample Provided: no

    Emedastine difumarate

    CAS: 87233-62-3

    Application:Emedastine Difumarate is the difumarate salt form of emedastine, a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result, this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva.

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