Diosmin

Chemical Name

Diosmin

CAS Number

520-27-4

Molecular Formula

C28H32O15

Molecular Weight

608.54

Molecular Structure

Storage

Store in well-closed container, keep away from strong light and heat.

Usage

Diosmin is a semisynthetic phlebotropic drug, a member of the flavonoid family. It is used with with Hesperidin to control internal symptoms of hemorrhoids (piles). It is an oral phlebotropic drug used in the treatment of venous disease.

Items

Specification

Appearance

Greyish-yellow or light yellow hygroscopic powder

Solubility

Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.

Identification

Meets the Requirements

Water

≤6.0%

Heavy Metals

≤20ppm

Sulphated Ash

≤0.2%

Bulk Density

0.55g/ml ~ 0.66g/ml

Iodine

≤0.1%

Related Substances (HPLC)

Acetoisovanillone ≤1.0%; Hesperidin ≤5.0%

Isorhoifin ≤3.0%; Linarin ≤3.0%; Diosmetin ≤3.0%

Any other impurity ≤1.0%;Total ≤10.0%

Total of other impurities and impurity A ≤1.0%

Assay (HPLC)

90.0% ~ 102.0%

Residual Solvents

Methanol ≤3000ppm

Ethanol ≤5000ppm

Pyridine ≤200ppm