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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia
Packaging Information: 25kg/drum
Delivery Lead Time: 1 week
Sample Provided: yes
Payment Terms: T/T
Name: Diosmin
CAS#: 520-27-4
Botanical Source: Immature bitter orange
Specification:EP, HPLC 90%--98%, Micronized Powder or Granule
Function & Application: Diosmin is a drug used to treat various symptoms related to the acute attack of hemorrhoids. It can also be used to treat various symptoms related to venous lymphatic insufficiency (feelling of heaviness of the legs, pain, soreness and discomfort in the morning).
TEST ITEM
STANDARD
RESULT
Appearance
Greyish-yellow or light yellow hygroscopic powder
Complies (Visual)
Melting point
277℃-278℃
Complies(Melting point apparatus)
Identification
(a)(b) Must Positive
Complies
Solubility
- in water
Insoluble
Complies
- in dimethyl sulfoxide
Soluble
Complies
- alcohol
Insoluble
- dilute solutions of alkali hydroxides
Soluble
Residue on ignition
≤0.5%
Complies
Mesh size
100% pass 80 mesh/2000 mesh
Complies
Iodine
≤0.1%
Complies (Potentiostat)
Related substances
- acetoisovanillone
≤0.5%
Complies (HPLC)
- hesperidin
≤4.0%
Complies (HPLC)
- isorhoifolin
≤3.0%
Complies (HPLC)
- 6-iododiosmin
≤0.6%
Complies (HPLC)
- linarin
≤3.0%
Complies (HPLC)
- diosmetin
≤2.0%
Complies (HPLC)
- unspecified impurities
≤0.4%
Complies (HPLC)
- total
≤8.5%
Complies (HPLC)
Heavy metals
90%---102%
Complies (HPLC)
Water
≤6.0%
Complies (K.F)
Residual solvents
- methanol
≤3000ppm
Complies (HPGC)
- acetic acid
≤5000ppm
Complies (HPGC)
- pyridine
≤200ppm
Complies (HPGC)
Assay
MICROBIOLOGICAL TEST
STANDARD
RESULT
Total microbial count
≤1000cfu/g
Complies
Yeast & mold
≤100cfu/g
Complies
E.Coli
Negative
Negative
Salmonella
Negative
Negative
Packaging: The usual packaging is 25kg net carton drum or box with a polyethylene bag in side.
Storage: Preserve in well closed,light resistant and dry environment.
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Pharma Sources Insight June 2024: Globalization on the Go
