Diminazene Aceturate

【name】Diminazene Aceturate
【CAS NO.】536-71-0
【description 】yellow or orange, crystalline powder, odourless, with light, when it is heated to orange red. Dissolved in water, almost insoluble in ethanol, insoluble in chloroform and ether.
【pharmacological action】three nitrogen amidine belongs to aromatic amidine class, is the traditional use of broad-spectrum resistance to blood parasite drugs, such as livestock pear-shaped, trypan and no body has the treatment function, but the prevention effect is poor.
Aromatic double amidine class insect-resistant role, with the interference of the insect body aerobic glycolysis and DNA synthesis. This kind of drug can cause hypoglycemia host. Pear-shaped worm and trypan aerobic glycolysis to rely on a host of grape sugar. Allegedly killed trypan role of drugs in the class, depending on its inhibitory effect of trypan aerobic glycolysis and nuclear protein denaturation process. For example, three nitrogen amidine can selectively block trypan dynamic matrix
Kinetoplast DNA synthesis or copy, namely three nitrogen amidine can rapid irreversible combined with trypan contain DNA organelles, usually three nitrogen amidine a molecule that can combine with 4 ~ 5 DNA nucleotides. Because of three nitrogen amidine DNA complex inhibit DNA synthesis, dynamic matrix trypan cannot reproduce and insect-resistant effect into full play.
【Limited】(1) the cow three nitrogen amidine have different effect on different genus pear-shaped worm. Such as bovine double shoots barber of cattle, as low as 0.5 mg/kg quantity is effective; 3.5 mg/kg amount healed, insect body disappear after 24 h, temperature recovery is often, curative effect was 100%.
This product to divide barber, insect, cattle barber, poor effect, use four days later, there is still a bug in the blood, but already obviously improve clinical symptoms, such as the rise in temperature drop, reduce mortality, etc.
Three nitrogen amidine for most pear-shaped insect prevention effect is not good.
No form of cattle, interval of 24 ~ 48 h, the secondary injection 7 ~ lOmg/kg, also has a good effect.
It is reported that three nitrogen amine for certain African trypanosomiasis prevention has a good effect.
(2) the horse three nitrogen amidine on crossbows barber worm has fine effect, can completely remove the insect body, but the barber worm therapy effect is poorer, need 6 ~ 12 mg/kg dose, to be effective. But increase the dose, easy to appear toxic effects.
Recently, someone proved that the barber about horse worm, need 5 mg/kg dose, interval of 24 h, Ed twice, can cure.
Three nitrogen amidine covering about horse disease also have good results, with mild infection, usually by 3.5 mg/kg/day, stay 3 days, 24 h insect body disappeared after treatment, food drink gradually returned to normal, edema disappeared; But severe infection, the horses to be according to the quantity of 5 ~ 7 mg/kg/day, and should according to specific condition and longer course of treatment.
(3) the dog, cat 5 mg/kg recommended doses of three nitrogen amidine, clinical symptoms were caused by canine barber, worm elimination effect obviously. But for dog dress barber, insect, need apply 7 mg/kg dose, can thoroughly remove the insect body, but the dose to the dog is can cause obvious central nervous system disease.
Three nitrogen amidine barber about cat cat bug is invalid, but the cat Babesia. Herpailuri effectively.
【 usage and dosage 】 an intramuscular injection quantity per LKG weight horse 3 ~ 4 mg cattle and sheep in the 3 ~ 5 mg of 5% ~ 7% sterilization solution made up with before
【 notes 】 (1) chemical amidine, bigger toxicity safety range is relatively narrow, treatment sometimes also can appear adverse reactions, but usually can self resistance. Excitant strong injection of local organizations, and the reaction of the horse is more serious, so the large dose should be equinoctial deep intramuscular injection.
(2) the camel to this product is sensitive to need not advisable, sensitive, with large dose carefully; Buffalo is cattle sensitive, especially when continuous application, easy appear toxic effects.
(3) large doses can reduce cows milk production.