DHA-1（ALC-0315 Analog 1）

ALC-0315 Analog 1 is a synthetic cationic lipid commonly used in drug delivery systems, particularly in gene therapy and vaccine development based on lipid nanoparticles (LNPs). ALC-0315 and its analogs can effectively encapsulate and protect nucleic acids (such as mRNA) and deliver them to target cells by forming stable lipid bilayer structures. These lipid molecules typically feature ionizable head groups that carry a positive charge under physiological pH conditions, enabling them to bind with negatively charged nucleic acids and form complexes.

ALC-0315 Analog 1 may have undergone specific structural modifications to ALC-0315 to optimize its physicochemical properties, such as enhancing stability, improving cellular uptake efficiency, or reducing toxicity. This class of lipids has played a crucial role in the development of mRNA vaccines (e.g., COVID-19 vaccines), as they significantly improve the delivery efficiency and expression efficacy of nucleic acids.