Dexmedetomidine Hydrochloride Injection

Indications:

1. Anti-inflammation and anti-allergy: The mechanism of action is mainly through inhibiting the release of inflammatory substances in leukocytes and macrophages, and inhibiting their aggregation at the inflammatory site, thereby reducing the release of histamine, relieving inflammation, and achieving relief of inflammatory symptoms, The effect of preventing and alleviating allergies;

2. Anti-toxin and anti-shock: By fighting the toxins produced by pathogens, reducing the stimulation to the body, achieving a protective effect on the body, improving the body's ability to respond to injuries, and playing an anti-shock effect;

3. Immunosuppression: mainly by inhibiting the proliferation of immune cells T cells and B cells, so as to achieve the effect of immunosuppression.

Precautions:
1. It should be used with caution in patients with tuberculosis, acute bacterial or viral infection, and appropriate anti-infective treatment must be given when necessary.

2. After taking the medicine for a long time, the dosage should be gradually reduced before stopping the medicine.

3. It should be used with caution in patients with diabetes, osteoporosis, liver cirrhosis, renal insufficiency, and hypothyroidism.

Pharmacokinetics:

Blood concentration peaked 8 hours after intramuscular injection of dexamethasone acetate. The plasma protein binding rate was lower than that of other corticohormone drugs.