Cnidium Monnieri Extract

About The Detailed Introduction Of Cnidium Monnieri Extract?

The osthole in Cnidum extract is a botanical insecticide extracted and processed from the Cnidium plant of the Umbelliferae family. Cnidol is a coumarin compound. Prismatic crystals (diethyl ether), needle crystals (dilute ethanol). The melting point is 83~84℃ and the boiling point is 145~150℃. Soluble in alkali solution, ethanol, methanol, chloroform, acetone, acetic acid, ethyl ester, chloroform, etc., but insoluble in water and petroleum ether. It is stable under normal pressure and temperature conditions, and has no decomposition in solutions with a pH of 5 to 9. Cnidol is a low-toxic pesticide.
Cnidium monnieri is a plant, also called wild carrot seed, which is picked in summer and autumn. It has a mild temperament and a slightly bitter taste. Cnidium monnieri extract is extracted from the fruit of the Umbelliferae plant Cnidium monnieri (L.) Cuss. Its active ingredients include pinene, bornyl isovalarate, and parsley methyl. Ether (osthol), dihydroanthol, berapten, cnidiadin, isopimpinellin, etc. It can be used as an additive in pharmaceutical and health products and functional beverages.
Cnidium monnieri extract is derived from the fruit of Cnidium monnieri (L.) Cusson. Mainly produced in Hebei, Shandong, Jiangsu, Zhejiang, Sichuan, Inner Mongolia, Shaanxi, Shanxi and other places. Harvest the fruits when they are mature in summer and autumn. Pick the fruits or cut off the above-ground parts to dry in the sun, knock the fruits off, and sift or remove impurities. The main active ingredients of Cnidoma monnieri are several coumarin compounds, among which the content of osthole is relatively high. Cnidium monnieri is warm in nature, bitter in taste and slightly poisonous. It can be used externally to remove dampness, kill insects and relieve itching, and be used internally to warm the kidneys and strengthen yang, dispel wind and dry dampness. It is used to treat impotence, uterine cold, cold arthralgia and low back pain, external treatment of trichomonal vaginitis, tinea pedis infection of hands and feet, etc. According to modern pharmacological research, Cnidium monnieri has anti-mutagenic and anti-arrhythmic effects.

What Are The Benefits? 

Anti-Trichomoniasis Effect
Cnidium monnieri is used externally in traditional Chinese medicine to treat trichomonas vaginitis, but the effect of a single agent is poor or very weak, while the compound Cnidoma monnieri suppository or lotion is very effective. Oosthole has the effect of killing Trichomonas vaginalis in vitro, with the lowest effective concentration being 1.12 mg/ml.
Sex Hormone-Like Effects
Cnidium monnieri ethanol extract, injected subcutaneously into mice every day for 32 consecutive days, can prolong the estrous period, shorten the inter-estrus period, and cause estrus in castrated mice. The weight of the ovaries and uterus will increase. It has similar sex hormone-like effects on the prostate. , seminal vesicles, and levator ani muscles to increase weight (mice) prove that Cnidium monnieri extract has androgen-like effects. It has no corrosive effect on rabbit vaginal mucosa.
Antiasthmatic Effect
The total coumarins in Cnidoma monnieri have anti-asthmatic effects, which can significantly reduce or eliminate wheezing in the lungs of asthma patients, significantly increase the peak expiratory flow rate, and improve lung ventilation function. It also has a certain expectorant effect. It has a significant protective effect on experimental asthma in guinea pigs caused by inhalation of spasmodic agents.
Antifungal Effect
Oosthole, bergamot lactone and isosaxifrage have strong activity against Trichophyton mentagrophytes in in vitro tests; Zanthoxylin has significant antifungal effect.
Inhibits The Heart And Dilates Blood Vessels
Experimental results show that on the one hand, osthole has the effect of inhibiting the heart and affecting myocardial contractility; on the other hand, osthole has the effects of lowering blood pressure and dilating blood vessels, reducing cardiac pre- and post-load, reducing cardiac burden, and reducing cardiac oxygen consumption. It shows that osthole has the effect of relaxing vascular smooth muscle.
Hypolipidemic Effect
Oosthole can reduce serum triglyceride (TG) levels. Further research results show that osthole can reduce total cholesterol (TC) and TG content in the liver of animals with fatty liver, suggesting that it has a good effect on animal fatty liver. Therapeutic effect.
Reduce Cerebral Infarction
Oosthole can improve the neurological behavioral deficit scores after cerebral ischemia-reperfusion in rats, reduce cerebral edema and the scope of cerebral infarction, enhance the activities of Na+, K+-ATPase and Ca2+-ATPase, and reduce the activity and activity of MPO in brain tissue. Amount of IL-8. Conclusion: Oosthole has a protective effect on cerebral ischemia-reperfusion injury.
Sedative Effect
Oosthole significantly enhances the hypnotic effect of subthreshold hypnotic dose sodium  in mice, and this effect is dose-related.
Anti-Inflammatory Effect
Oosthole can significantly inhibit acute and chronic inflammation, reduce the swelling of the ear shell caused by xylene and the increased permeability of abdominal capillaries in mice caused by acetic acid, significantly inhibit the granuloma caused by agar in mice, and inhibit carrageenan and Bilateral adrenalectomy-induced plantar swelling in rats was significantly inhibited.

Extraction Method

1. Water Decoction Method: Precisely weigh 1g of Cnidium monnieri medicinal powder, place it in a 50ml ground-mouth conical flask with a stopper, add 20mL of distilled water, heat and extract for 1 hour, filter to obtain the filtrate, and evaporate the filtrate to dryness to obtain the infusion. The extract is completely dissolved with methanol and then filtered. The filtrate is transferred to a 100mL volumetric flask and diluted to the mark. The test solution is obtained by filtering through a 0.45μm microporous filter membrane.
2. Ethanol Ultrasonic Extraction Method: Precisely weigh 1g of Cnidium monnieri medicinal powder, place it in a 50ml stoppered ground-mouth conical flask, add 20mL of 95% ethanol, conduct ultrasonic extraction for 1 hour at room temperature (30±1°C), and filter , get the filtrate, evaporate the filtrate to dryness to get the extract, dissolve the extract completely with methanol and filter, transfer the filtrate into a 100mL volumetric flask and dilute to the mark, filter through a 0.45μm microporous membrane to get the test solution.
3. Alkaline Water Immersion Extraction Method: Precisely weigh 1g of Cnidium monnieri medicinal powder, place it in a 50ml stoppered ground-mouth conical flask, add 20ml of 1% NaOH solution, soak at room temperature (30±1℃) for 6h, and use 1096Hcl After acidification, centrifuge and collect the precipitate. The precipitate is completely dissolved in methanol and then filtered. The filtrate is transferred into a 100 mL volumetric flask and the volume is adjusted to the mark. The test solution is obtained by filtering through a 0.45 μm microporous membrane.
4. Alkali-Soluble Acid Precipitation Ultrasonic Extraction Method: Precisely weigh 1g of Cnidoma monnieri medicinal powder, place it in a 50ml stoppered ground-mouth conical flask, add 20ml of 1% NaOH solution, soak at room temperature for 1h, and perform ultrasonic extraction for 10 minutes. Acidify with 10% HCI and centrifuge to collect the precipitate. Take its precipitate. The precipitate is completely dissolved in methanol and then filtered. The filtrate is transferred to a 100mL volumetric flask and diluted to the mark. The test solution is obtained by filtering through a 0.45μml microporous membrane.

What Are The Application Directions?

Pharmaceutical Field:
Cnidium monnieri extract has a variety of pharmacological and bioactive components, so it plays an important role in traditional medicine. It is used in traditional Chinese medicine preparations, such as Cnidium monnieri capsules and Cnidium monnieri tablets, to treat rheumatism, arthritis, muscle and bone pain and other symptoms. Cnidium monnieri extract can also be used as pharmaceutical raw materials for the production of anti-tumor drugs, anti-viral drugs, etc.

Health Care Products Field:
It is also widely used in the field of health care products. Because of its antioxidant, immunomodulatory, anti-inflammatory, and immune-improving effects, it can be used to make health care products, such as Cnidoma monnieri health capsules, Cnidoma monnieri oral liquid, etc. These health products are often recommended to people who need to enhance immunity, improve physical fitness, relieve fatigue, etc.

Agriculture:
It also has certain applications in the agricultural field. It can be used as a plant growth regulator to promote plant growth and development and enhance plant stress resistance. In addition, Cnidium monnieri extract can also be used for plant protection and has certain control effects on some diseases and insect pests.

Other Areas:
It is also used in other fields. For example, in the field of cosmetics, Cnidium monnieri extract can be used in skin care products with anti-aging, antioxidant, whitening and other effects. In the food industry, Cnidium monnieri extract can be used as a food additive to improve the taste and nutritional value of food.

Company Introduction And Certificates Obtained

Shaanxi Yuantai Biological Technology Co., Ltd (YTBIO) was established in 2014, mainly supplying Cnidium monnieri extract etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

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