Clozotinib

Name: Clozotinib
Availability: clozotinib-343796.html

Category:Active Pharmaceutical Ingredients
Product Name:Clozotinib
CAS No.:877399-52-5
Standard:In-house Standards
Price(USD):Negotiable
Company:Shanghai Hope-chem Co.,Ltd.

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Basic Info

Grade: pharmaceutical grade

Factory Location: Shanghai

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no

Clozotinib is an oral aminopyridine inhibitor that is an inhibitor of receptor tyrosine kinase (ALK) and c-Met/hepatocyte growth factor receptor (HGFR), exhibiting anti-tumor activity. Clozotinib competitively binds to ALK kinase and ALK fusion protein in an ATP competitive manner and inhibits them. In addition, clotozantinib can also inhibit c-Met kinase and disrupt the c-Met signaling pathway. Overall, this medication can inhibit the growth of tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in the development of the nervous system. ALK dysregulation and gene rearrangement are associated with a range of tumors.

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