Ciprofloxacin HCL

Category:Active Pharmaceutical Ingredients > Other Anti-Infective Drug
Product Name:Ciprofloxacin HCL
CAS No.:85721-33-1
Standard:ChP, USP, EP
Price(USD):0.00
Company:Arshine Group Co.,Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Block 14, No.100, Luyun Road, Changsha 410205, Hunan, China.

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Sample Provided: no

    Payment Terms: T/T,L/C,DP,Bank Contract.

    Ciprofloxacin is an antibiotic used to treat a number of bacterial infections. This includes bone and joint infections, intra abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. For some infections it is used in addition to other antibiotics. It can be taken by mouth, in eye drops, or intravenously.

    1. Cipofloxacin HCl drug is used for the treatment of Bacterial infection of Respiratory tract, UTI, Uncomplicated Cystitis in females, GI, Chronic Bacterial Prostatitis, CNS, Immuno compromised patients, Skin, Bone and Joint Infections, Uncomplicated cervical and urethral gonorrhea.

    2. Ciprofloxacin HCl drug has in vitro activity against a wide range of gram-negative and gram-positive organisms.

    3.Ciprofloxacin HCl drug inhibits bacterial DNA gyrase, an enzyme responsible for counteracting excessive supercoiling of DNA during replication or transcription. The mechanism of action of quinolones, including Ciprofloxacin HCl drug, is different from that of other antimicrobial agents such as betalactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to Ciprofloxacin HCl drug. There is no known crossresistance between ciprofloxacin HCl drug and other classes of antimicrobials

    Tests

    Acceptance Criteria

    Results

    Characters

    Appearance

    Faintly yellowish to light yellow crystalline powder.

    Faintly yellowish

    crystalline powder

    Solubility

    Sparingly soluble in water; slightly soluble in acetic acid and methanol; very slightly soluble in dehydrated alcohol; practically insoluble in acetone, in acetonitrile, in ethyl acetate, in hexane, and in methylene chloride.

    /

    Identification

    IR: Conforms to the spectrum of Ciprofloxacin Hydrochloride RS.

    HPLC: The retention time of the major peak of the Sample solution corresponds to that of the Standard solution , as obtained in the Assay .

    Responds to the tests for chloride.

     

    Conforms

    pH

    3.04.5 (lg/z40ml water)

    3.8

    Water

    4.7 -6.7%

    6.1%

    Residue on ignition

    0.1%

    0.01%

    Heavy metals

    W 0.002%

    0.002%

    HPLC

    Chromatographic purity

    1)

    Ciprofloxacin ethylenediamine analog

    W0.2%

    0.07%

    2)fluoroquinolonic acid

    W0.2%

    0.09%

    2)Any other individual impurity

    W0.2%

    0.05%

    3)The sum of all impurities

    W0.5%

    0.12%

    (HPLC)Assay

    98.0%102.0% of C17H]gFN3O3 • HCL (On the anhydrous substance)

    99 6%

    Residual solvents

     

    (1) Ethanol

    W5000ppm

    315ppm

    (2)Toluene

    W890ppm

    Not detected

    (3) I so amyl alcohol

    W2500ppm

    Not detected

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