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Category:Active Pharmaceutical Ingredients
Product Name:carbenicillin,carbenicillin disodium salt
CAS No.:4800-94-6
Standard:In-house Standards
Price(USD):0.00
Company:Hangzhou Dingyan Chem Co., Ltd
Grade: Pharmaceutical Grade
Factory Location: hangzhou
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
Carboxybenzpenicillin is mainly used for pseudomonas aeruginosa and some proteus bacillus, escherichia coli caused by otitis media, pneumonia, endocarditis, cystitis, pyelonephritis, postoperative meningitis, sepsis, biliary tract infection, skin and soft tissue infection. Do skin test before use. Do not use if allergic to penicillin. The toxicity of this product is small, but some patients also have elevated aminotransferase. Local pain is more obvious after intramuscular injection, so intravenous injection is often used.
Octadecyl silane bonded silica gel was used as filler in chromatographic condition and system suitability test. The mobile phase was 0.02mol/L potassium dihydrogen phosphate solution (pH value adjusted to 3.4 0.1 with 10% phosphoric acid) -methanol (55:45). The detection wavelength was 225nm. The number of theoretical plates should not be less than 2000, and the separation degree between ampicillin and cloxacillin should meet the requirements.
The contents under the difference of loading amount in the determination method were taken, accurately weighed, dissolved and diluted with mobile phase to make 0.5mg solution in every 1ml, which was used as the test solution. In addition, an appropriate amount of ampicillin and cloxacillin was weighed, and the solution containing 0.25mg in each 1ml was dissolved in mobile phase and diluted, respectively. As the reference solution, the sample solution and the reference solution of 20 l were respectively injected into the liquid chromatograph, and the chromatogram was recorded.
According to the external standard method, the content of C16H19N3O4S and C19H18ClN3O5S in the test products were calculated by peak area.
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