Camptotheca Acuminata Extract

Product name: Camptotheca Acuminata Extract

Latin Name: Camptotheca Acuminata

Other Name: 7-Ethyl-10-hydroxy camptothecin

Specification: 98% Camptothecin (HPLC) 

Appearance: Light yellow fine powder.

CAS No.: 86639-52-3 / 7689-03-4(Camptothecin )

Molecular formula: C22H20N2O5

Mol.weight:(392.40)

Botanical Source: Nothapodytes Pittosporoides sleum, or semi-synthesis fro Camptotheci

Physical Properties : melting point 259 -263, soluble alkaline solution

Where will  Camptothecin be used for?

1. Anti-tumor effect; Immunosuppressive effect;

2. Camptothecin and 1O-methoxy  camptothecin in on herpes simplex virus had significant inhibitory action. Camptothecin 5mg / kg, 1 times daily, continuous1-3 gavage or subcutaneous injection of 7- 9 day after mating, the rats and 7 days after mating in may 100% anti early pregnancy.

Application Of  Camptothecin:

1.Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

2.In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.

3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.

4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

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