Cabozantinib malate

Name: Cabozantinib malate
Availability: cabozantinib-malate-343798.html

Category:Active Pharmaceutical Ingredients
Product Name:Cabozantinib malate
CAS No.:1140909-48-3
Standard:In-house Standards
Price(USD):Negotiable
Company:Shanghai Hope-chem Co.,Ltd.

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Basic Info

Grade: pharmaceutical grade

Factory Location: Shanghai

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no

Malic acid cabozantinib is the malate form of cabozantinib, which is an orally bioavailable small molecule receptor tyrosine kinase (RTK) inhibitor with potential anti-tumor activity. Cabozantinib strongly binds and inhibits several RTKs, which are typically overexpressed in various cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearrangement during transfection), vascular endothelial growth factor receptor type 1 (VEGFR-1), type 2 (VEGFR-2), and type 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin associated kinase B (TRKB), and AXL. This may lead to inhibition of tumor growth and angiogenesis, ultimately leading to tumor regression.

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