BMS-986165

Name: BMS-986165
Availability: bms-986165-310832.html

Category:Active Pharmaceutical Ingredients
Product Name:BMS-986165
CAS No.:1609392-27-9
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Price(USD):Negotiable
Company:Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd.

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: Zhongcheng Future Industrial Park, Hangcheng Avenue, Baoan District, Shenzhen

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Contract Manufacturing: CRO,CMO
Sample Provided: no

Payment Terms: L/C

Description:Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).

Target:Tyk2

In Vitro:Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein.

In Vivo:Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours.

Molecular Formula：C20H19D3N8O3

Molecular Weight：425.46

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