Asiatic Acid Powder

What Is Asiatic Acid Powder?

Asiatic acid powder is one of the main components of the triterpene extract of the natural plant Centella asiatica (L.) Urban.
First isolated by Bontems in 1941, structure determined by Polonsky. Its chemical name: 2α, 3β, 23-trihydroxy-ursane-12-en-28-oic acid. Odorless, bitter taste, insoluble in water, soluble in absolute ethanol, dimethyl sulfoxide, tetrahydrofuran and other organic solvents.

Test Report

What Are The Benefits?   

The effect on skin care
Since Chasseaud et al. determined that Asiatic acid itself has the effect of treating skin wounds in 1971, Centella Asiatica extract (mainly containing Asiatic acid and Asiatica saponin) has been used to treat skin wounds and chronic ulcers. Treatment of skin deformities caused by tuberculosis and leprosy.

Antibacterial effect
Studies have found that asiatic acid has good inhibitory effects on Candida albicans, Candida krusei, Cryptococcus neoformans, Escherichia coli, Sporothrix schenckii, Bacillus subtilis, Staphylococcus aureus, Shigella and other microorganisms effect.

Antidepressant effect
In order to improve the bioavailability of drugs, Li Tiejun et al. synthesized salt derivatives such as sodium asiatic acid and ammonium, and used the classic mouse tail suspension and forced swimming experiment models to find that asiatic acid, sodium asiatic acid and hydroxyl product Noticic acid at a dose of 30 mg/kg can significantly shorten the immobility time of tail suspension and forced swimming in mice. In addition, in the experiment of antagonizing the ptosis of mouse eyelids caused by reserpine, they also found that asiatic acid sodium salt, asiatic acid and hydroxyasiatic acid had obvious antagonism at a dose of 60 mg/kg, and the effect was significantly better than that of asiatic acid. Doxepin is listed as a tricyclic drug, so it can be judged that asiatic acid and its derivatives have strong antidepressant activity.

Hypoglycemic effect
It can significantly increase the glucose excretion of alloxan-induced diabetic mice. The specific effect is not yet clear, and it may achieve the effect of lowering blood sugar by inhibiting the activity of glycogen phosphorylase. It can resist the reduction of the cell membrane potential, superoxide dismutase (SOD), ATPase, catalase (CAT) activity of myocardial mitochondria in diabetic rats induced by streptozotocin, and play a certain role in the complications of diabetes Relief.

Anti-inflammatory effect
According to reports, it can significantly inhibit the increase of interleukin-8 (IL-8) secretion caused by tumor necrosis factor (TNF-α), and has obvious anti-inflammatory effect. It can significantly inhibit the inflammatory response of RAW264.7 cells induced by LPS, and its mechanism is to play a role by reducing the amount of NO and the secretion of TNF-α. Due to its good anti-inflammatory effect, asiatic acid has been used clinically in the treatment of surgical diseases and in the field of beauty care, such as skin wounds, chronic ulcers, delayed wound healing, surgical injuries and cellulitis, and shampooing, etc. .

Protection against liver damage
It can inhibit the activation and transformation of rat hepatic stellate cells (HSC-T6), reduce the expression of alpha actin (alpha-SMA), and thereby inhibit liver fibrosis. The mechanism of liver protection is by protecting the mitochondria of liver cells and scavenging superoxide anion and hydroxyl free radicals. Studies have shown that asiatic acid can inhibit the activation and transformation of rat hepatic stellate cells induced by TGF-β. Asiatic acid up-regulates the negative feedback signal of Smad7 mRNA, and prevents TGF-β-induced type Ⅰ collagen synthesis in rat hepatic stellate cells through Smad7, thereby achieving the effect of inhibiting liver fibrosis. Asiatic acid is a drug that can significantly resist liver fibrosis. Its analogs have a strong protective effect on hepatotoxicity induced by galactosamine and carbon tetrachloride. In view of the current extensive research prospects of triterpenoids, and Asiatic acid is stronger than oleanolic acid (OA) and ursolic acid (UA) in scavenging free radicals and protecting mitochondria, Asiatic acid has the potential to be developed The prospect of becoming a new liver-protecting drug.

Application Direction

Anti-irritant; skin repair, inhibit collagen synthesis; improve keratinization function; stimulate skin cells, etc. Therefore, it is used in the field of cosmetics.
Asiatic acid powder also has a wide range of pharmacological effects, and can also be used in the field of medicine and health products

Company Introduction And Certificates Obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

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