An Leaf Summer Extract

An Leaf Summer Extract
Product Name: An Leaf Summer Extract
Botanical Name: Suffrutescent Securinega Twig
Part Used: velamen
Specification: 10:1
CAS No：5610-40-2
Molecular Formula: C13H15NO2
Molecular Weight: 217.2637
Appearance: Tan Powder

What is An Leaf Summer Extract?
Securinine is the major alkaloid natural product from the root of the plant securinega suffruticosa. It was originally discovered over 50 years ago and reported to have potent biological activity. Though this compound has not been utilized in the United States, it has been used clinically in several other countries particularly China and Russia. In China it is considered one of the 50 fundamental Chinese herbs and is used in Chinese herbal medicine . Securinine has been found to be active as a γ-amino butyric acid (GABA) receptor antagonist. Its activity as a GABA antagonist, likely explains its reported clinical success in limited studies for the treatment of neurological conditions such as amyotrophic lateral sclerosis (ALS), poliomyelitis and multiple sclerosis . Though securinine has never been previously tested clinically as an anti-cancer agent, there is a single report that demonstrates that it can induce apoptosis at high doses in a leukemic cell line . In addition, we have recently found that securinine may have potential utility against certain types of colon cancer. Finally, securinine has also been reported to induce macrophage activation and therefore proposed as a potential therapeutic for infectious processes. Here we demonstrate that securinine can induce AML differentiation and has potential as an AML therapeutic.

Where will  An Leaf Summer Extract be used to?
l-Securinine has an anti-tumor effect against colon cancer SW480 cell. The l-securinine can induce striking autophagy in SW480 cell in vitro. The autophagy induced by l-securinine is related with upregulating the expression of autophagy gene Beclin-1.

Application of NutraMax’s An Leaf Summer Extract
1Leaves, flowers and fruits all can be used as a medicine, for central nervous system and heart stimulants, can strengthen the heart contraction.
2Leaves and flowers contain alkaloids can be made into bead alkali nitrate leaves, and paralysis caused by spinal cord grey matter inflammation can be cured and impotence.
3Bark and branches can be extracted as fiber and can be used for rope and textile materials;
4It can press oil for industrial use