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Category:Intermediates > Pharmaceutical Intermediates Product Name:Amyloid beta-protein fragment 1-40 CAS No.:131438-79-4 Standard:In-house Standards Price(USD):Negotiable Company:Hangzhou Go Top Peptide Biotech Co.,Ltd.
Factory Location: Hangzhou economic development zone no. 6 street 5 b03 high-tech incubator building 1, 452
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
Payment Terms: L/L
Alzheimer's disease (AD) is a kind of onset conceals the progressive development of the nervous system degenerative disease.
Clinically to memory impairment, aphasia, disuse, agnosia, depending on the spatial skills damage, executive dysfunction and comprehensive performance for dementia characteristics such as personality and behavior change.
Epidemiological studies have shown that non-steroidal anti-inflammatory drugs (epoxy) synthase inhibitors can prevent or delay the onset of alzheimer's disease, brain inflammatory before clinical symptoms promote disease progression.
Beta amyloid protein can cause inflammatory cytokines and microglia activation, this process will release hydrogen peroxide, TNF alpha and beta IL - 1 killer factor.
Hydrogen peroxide promote microglia proliferation, TNF alpha beta (tumor necrosis factor) and IL - 1 (interleukins) is a very powerful biological activity factor, can quickly kill the pathological changes of neurons.
And activated inflammatory microglia will exist in alzheimer's patients for a long time of neuritis plaques.
Experiments found that beta-amyloid, cytokines and activated microglia can strong kill were cultured neurons, compared to beta Amyloid (1-42), beta Amyloid (1-40) has a better solubility in water.
So, kill microglia activation and prompted the pathological changes of neurons, is likely to be ultimately means for the treatment of such diseases.
Storage: - 20 ℃ under freeze dry, avoid light preservation remark: used only for research, not for human body