Amoxicillin capsules

Component:
Amoxicillin Capsules 500mg.

Character:
This product is a capsule, the content is white or white powder.

Indications:

Amoxicillin is suitable for the following infections caused by sensitive bacteria (strains that do not produce βlactamase) :

1. Otitis media, sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections caused by hemolytic streptococcus, streptococcus pneumoniae, staphylococcus or Haemophilus influenzae.

2. Urogenital tract infections caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis.

3. Skin and soft tissue infections caused by hemolytic streptococcus, staphylococcus or Escherichia coli.

4. Lower respiratory tract infections such as acute bronchitis and pneumonia caused by hemolytic streptococcus, Streptococcus pneumoniae, staphylococcus or Haemophilus influenzae.

5. Acute simple gonorrhea.

6. This product can also be used to treat typhoid fever, typhoid carriers and leptospirosis; Amoxicillin can also be combined with clarithromycin and Lansoprazole to eradicate Helicobacter pylori in stomach and duodenum and reduce the recurrence rate of digestive tract ulcer.

Usage and dosage:

By mouth. Adults 0.5g once, once every 6 to 8 hours, the daily dose is not more than 4g.

Children daily dose according to body weight 20 ~ 40mg/Kg, once every 8 hours; The daily dose for infants under 3 months is 30mg/Kg per body weight, once every 12 hours.

The dose should be adjusted for patients with severe renal impairment, and the endogenous creatinine clearance rate of 10-30ml/min was 0.25-0.5g every 12 hours. 0.25 to 0.5g per 24 hours for patients with endogenous creatinine clearance of less than 10ml/ min.

Precautions:

1. Penicillin oral drugs can cause anaphylactic shock, which is mostly seen in patients with a history of penicillin or cephalosporin allergy. Prior to medication, you must ask for a detailed history of drug allergy and do a skin test for penicillin. In case of anaphylactic shock, the patient should be rescued on the spot, with airway maintenance, oxygen inhalation, adrenalin, glucocorticoid and other therapeutic measures.

2. Patients with infectious mononucleosis are prone to rash when using this product, so it should be avoided.

3. Patients with longer treatment course should check liver, kidney function and blood routine.

4. Amoxicillin can lead to false positives in urine sugar tests using Benedict or Fehling reagents.

5. Caution should be exercised in the following cases:

(1) Patients with a history of allergic diseases such as asthma and hay fever.

(2) Dose adjustment may be required in the elderly and in cases of severe renal impairment.

Medication for special population:

Animal reproduction tests showed that amoxicillin at 10 times the human dose did not harm fertility and fetuses in rats and mice. However, there are not enough controlled studies in humans, and since animal reproductive tests cannot fully predict human reactions, pregnant women should only use this product when it is truly necessary. As a small amount of amoxicillin can be secreted in the milk, the nursing mother may cause allergies to the baby.

Drug interaction:

1. Methylsulfonamide competitively reduces renal tubule secretion, and the combination of the two causes an increase in amoxicillin concentration and a prolonged half-life.

2. Chloramphenicol, macrolides, sulfonamides and tetracycline interfere with the antimicrobial action of amoxicillin in vitro, but their clinical significance is unknown.