Albendazole

[name] Albendazole
【CAS NO 】  54965-21-8
【 characteristics 】 this product is white or kind of white powder; Odourless and tasteless. This product in acetone or slightly soluble in chloroform, almost don't dissolve in ethanol, insoluble in water; Dissolved in the glacial acetic acid.
[pharmacological action] (1) the pharmacodynamics Albendazole is the most widely used of veterinary clinical benzo imidazoles deworming drugs, it not only is efficient for a variety of nematodes, and also has strong for some fluke and tapeworm insect repellent effect.
(2) most pharmacokinetic benzo imidazoles deworming drugs because of low solubility and absorbed by the gastrointestinal medicine quantity is limited, but the albendazole belong to absorb the best of benzene and imidazoles deworming drugs, drug absorption after within 2 ~ 4 h can reach the peak blood, and for 15 ~ 24 h.
"Limited" anti-worm medicine. Used for livestock and poultry nematode, taeniasis and fluke disease.
【 usage and dosage 】 oral a quantity per 1 kg weight, 5 ~ 10 mg ma cattle, sheep 10 ~ 15 mg pigs 5 ~ 10 mg dog 25 ~ 50 mg poultry 10 ~ 20 mg.
Mix bait feeding: an amount per 1 kg weight, 0.2 g, fish once a day, stay 5 ~ 7 times.
【 notes 】 (1) albendazole is benzene and imidazoles wormer in a bigger toxicity, application of therapeutic dose not bring up the toxic reaction, but continuous drug overdosage, sometimes cause severe reactions. Combined with the application of dose than Europe and the United States is recommended (5 ~ 7.5 mg/kg), should be more careful to choose. In addition, certain breeds, such as horses, rabbits, cats have more sensitive to the drug, to choose other insect repellent is advisable.
(2) the continuous use for a long time, can make the worms become resistant, and benzene and imidazoles drugs may produce cross resistance.
(3) because the animal experiments proved that albendazole embryo toxicity and teratogenic effects, therefore, cattle and sheep in pregnancy within 45 days, pigs are disabled within 30 days of this product in pregnancy. The other animals in the gestation period is also not proper application of this product.