Acyclovir

Acyclovir CAS 59277-89-3 is an antiviral drug and a synthetic purine nucleoside analog. It is mainly used for various infections caused by herpes simplex virus. It can be used for initial or recurrent skin, mucosa, external genital infection and HSV infection in people with immune deficiency. It is the first choice drug for treating HSV encephalitis. It is better than adenosine arabinoside in reducing incidence rate and mortality. It can also be used for herpes zoster, EB virus, And immunodeficient individuals may develop infections such as chickenpox.

Acyclovir CAS 59277-89-3 can inhibit the thymidine kinase of herpes virus, with an IC50 of 530-750nM.

Acyclovir CAS 59277-89-3 has inhibitory effects on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. After entering cells infected with herpes virus, the product competes with deoxyribonucleoside for viral thymidine kinase or cell kinase. The drug is phosphorylated into activated acyclovir triphosphate and then inhibits virus replication in two ways: 1. Interfers with viral DNA polymerase to inhibit virus replication; 2. Under the action of DNA polymerase, it binds to the growing DNA strand, causing an interruption in the extension of the DNA strand. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. In vitro cell transformation assay has been reported to be carcinogenic, but animal experiments have not shown any evidence of carcinogenesis. Some animal experiments have shown that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes.

Acyclovir CAS 59277-89-3 is orally administered for the initial and recurrent cases of genital herpes virus infection, and for the prevention of recurrent cases. Injections are used for immunocompromised individuals. Treatment of initial and recurrent mucosal skin infections, as well as prevention of recurrent cases; Also used for the treatment of herpes simplex encephalitis. Oral administration is used for the treatment of mild cases of herpes in individuals with normal immune function and those with immunodeficiency. Injections are used for the treatment of severe herpes patients with immunodeficiency. Acyclovir CAS 59277-89-3 can also be used for the treatment of chickenpox in immunocompromised individuals; Localized treatment for early reproductive herpes infection caused by herpes simplex virus and initial and recurrent cases of self limiting mucosal skin herpes simplex in immunocompromised individuals.

Acyclovir CAS 59277-89-3 sodium salt for the treatment of acute retinal necrosis. Nucleotide based antiviral drugs for the treatment of herpes simplex keratitis; Herpes simplex; Herpes zoster; Treat acute retinal necrosis with its sodium salt. Mainly used for superficial and deep keratitis caused by herpes simplex virus and herpes zoster virus.