99% up by HPLC injection grade Cisatracurium Besylate 96946-42-8

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:99% up by HPLC injection grade Cisatracurium Besylate 96946-42-8
CAS No.:96946-42-8
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen, Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

  • Monthly Production Capacity: 1000kg

    Packaging Information: 25kg/drum 1kg/bottle

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

    Product Information

     

    Product name

    Cisatracurium besylate

    CAS No.

    96946-42-8

    Molecular Formula

    C53H72N2O12.2C6H5O3S

    Molecular Weight

    1243.49

    Quality Standard

    99% up, Medicine Grade, Injection Grade

    Appearance

    White powder

     

    COA of Cisatracurium besylate

     

      TEST

    STANDARD

    RESULT

    Appearance:

    white or almost white powder, slightly hygroscopic, ordorless

      Confirms

    Very solutable in acetonitrile or chloroform, Soluble in Water, very soluble and practically insolutable in ethyl ether

      Confirms

    Identification

    (1)     IR

    Conforms

    (2)     HPLC

    Conforms

    Water

    NMT 5.0%

    0.6%

    Residue on ignition

    NMT 0.2%

    0.1%

    Methyl benzenesulfonate

    NMT 0.1%

    undetected

    Toluene

    NMT 890ppm (ICH)

    102ppm

    Chromatographic purity

    (1) Laudanosine: NMT 0.5%

    (2) Other individual impurities: NMT 1.0%

    (3) Total Impurities: NMT 3.5%

    0.01%

    0.38%

    1.3%

    Isomer Ratio

    Trans-Trans Isomer: 5%-6.5%

    5.7%

     

    Cis-Trans Isomer: 34.5%-38.5%

    36%

     

    Cis-Cis Isomer: 55%-60%

    58.2%

    Assay

    96%-102%

      (C65H82N2O18S2 on anhydrous basis)

    100.2%

    Residue Solvents

    (1) Dichloromethane: NMT 600ppm

    (2) Acctonitrile: NMT 410ppm

    (3) Ethyl ether: NMT 5000ppm

    Undetected

    Undetected

    1739ppm

    Result

    Confirms to USP34

     

    Usage

     

    Function of Cisatracurium besylate

    Cisatracurium besylate is the latest generation of muscle relaxants. Compared with the main clinical muscle relaxant anesthetics, this product has the characteristics of metabolism through non-hepatic and non-renal pathways and cardiovascular stability. Tracurium is 3 times stronger and has no cardiovascular side effects. Cisatracurium is mainly used for general anesthesia, and can be widely used in tracheal intubation, liver and kidney dysfunction, cardiovascular surgery, and elderly and pediatric patients. Since the drug was first marketed in the UK in 1996, foreign countries have gradually replaced vecuronium and atracurium, becoming the mainstream of clinical muscle relaxants.

     

    At present, the most commonly used muscle relaxants in clinical practice are medium-term non-depolarizing muscle relaxants, such as Cisatracurium besylaterocuronium bromidevecuronium bromide, etc., and the three occupy almost the entire muscle relaxant market, reach to over 98%. Among them, cisatracurium besilate has the advantages of rapid onset, no cardiovascular side effects, no accumulation, and a wide range of applications. It is suitable for special patients such as the elderly, children, abnormal heart, liver and kidney function, and ICU patients. This is an ideal muscle relaxant. This variety has a rapid growth rate and has occupied more than 70% of the muscle relaxant market in 2019, and it can be described as a leader in the muscle relaxant market

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