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Email :PharmaSources@imsinoexpo.com
Whatsapp :+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Cisatracurium besylate
CAS No.
96946-42-8
Molecular Formula
C53H72N2O12.2C6H5O3S
Molecular Weight
1243.49
Quality Standard
99% up, Medicine Grade, Injection Grade
Appearance
White powder
COA of Cisatracurium besylate
TEST
STANDARD
RESULT
Appearance:
white or almost white powder, slightly hygroscopic, ordorless
Confirms
Very solutable in acetonitrile or chloroform, Soluble in Water, very soluble and practically insolutable in ethyl ether
Confirms
Identification
(1) IR
Conforms
(2) HPLC
Conforms
Water
NMT 5.0%
0.6%
Residue on ignition
NMT 0.2%
0.1%
Methyl benzenesulfonate
NMT 0.1%
undetected
Toluene
NMT 890ppm (ICH)
102ppm
Chromatographic purity
(1) Laudanosine: NMT 0.5%
(2) Other individual impurities: NMT 1.0%
(3) Total Impurities: NMT 3.5%
0.01%
0.38%
1.3%
Isomer Ratio
Trans-Trans Isomer: 5%-6.5%
5.7%
Cis-Trans Isomer: 34.5%-38.5%
36%
Cis-Cis Isomer: 55%-60%
58.2%
Assay
96%-102%
(C65H82N2O18S2 on anhydrous basis)
100.2%
Residue Solvents
(1) Dichloromethane: NMT 600ppm
(2) Acctonitrile: NMT 410ppm
(3) Ethyl ether: NMT 5000ppm
Undetected
Undetected
1739ppm
Result
Confirms to USP34
Usage
Function of Cisatracurium besylate
Cisatracurium besylate is the latest generation of muscle relaxants. Compared with the main clinical muscle relaxant anesthetics, this product has the characteristics of metabolism through non-hepatic and non-renal pathways and cardiovascular stability. Tracurium is 3 times stronger and has no cardiovascular side effects. Cisatracurium is mainly used for general anesthesia, and can be widely used in tracheal intubation, liver and kidney dysfunction, cardiovascular surgery, and elderly and pediatric patients. Since the drug was first marketed in the UK in 1996, foreign countries have gradually replaced vecuronium and atracurium, becoming the mainstream of clinical muscle relaxants.
At present, the most commonly used muscle relaxants in clinical practice are medium-term non-depolarizing muscle relaxants, such as Cisatracurium besylate, rocuronium bromide, vecuronium bromide, etc., and the three occupy almost the entire muscle relaxant market, reach to over 98%. Among them, cisatracurium besilate has the advantages of rapid onset, no cardiovascular side effects, no accumulation, and a wide range of applications. It is suitable for special patients such as the elderly, children, abnormal heart, liver and kidney function, and ICU patients. This is an ideal muscle relaxant. This variety has a rapid growth rate and has occupied more than 70% of the muscle relaxant market in 2019, and it can be described as a leader in the muscle relaxant market