99% up by HPLC, GMP Penciclovir 39809-25-1

Function of Penciciovir

Penciclovir is a nucleoside antiviral drug, which has inhibitory effect on type I and type II herpes simplex virus in vitro. In virus-infected cells, viral thymidine kinase phosphorylates penciclovir to penciclovir monophosphate, and cell kinase converts penciclovir monophosphate to penciclovir triphosphate. In vitro experiments show that penciclovir triphosphate and deoxyguanosine triphosphate competitively inhibit herpes simplex virus polymerase, thereby selectively inhibiting herpes simplex virus DNA synthesis and inhibition. Therefore, penciclovir is suitable for the treatment of a variety of herpes virus infections. It has the characteristics of low toxicity and high virus sensitivity. Penciclovir has low oral absorption and is often used for topical administration. Famciclovir is a prodrug of penciclovir and is well absorbed orally.